IL2RA interleukin 2 receptor subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: IL2RAprovided by VGNC
Official Full Name: interleukin 2 receptor subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:41977
See related: Ensembl:ENSCAFG00845002030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CD25; IL-2RA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (30275012..30330188)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (26924836..26975354)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (28928272..28977130)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (27372288..27422786)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (28208376..28259290)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Measurement of the concentration of serum soluble interleukin-2 receptor alpha chain in dogs with lymphoma.
Title: Measurement of the concentration of serum soluble interleukin-2 receptor alpha chain in dogs with lymphoma.
Data suggest that in dogs, as in humans, CD4(+) CD25(+) FoxP3(+) Tregs may contribute to the pathogenesis of canine atopic dermatitis as indicated by an association between Treg frequency and disease severity.
Title: Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity.
these findings suggest that the human and mouse model for protective response against Leishmania spp., which involves Th1 and macrophage modulation by interleukins 2, 15, gamma interferon and Notch signaling, may also hold for the canine model.
Title: Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling.
This study indicated that the activation of canine lymphocytes might induce the production of adaptive Treg cells, as observed in humans.
Title: Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables interleukin-2 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-2 receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-2 receptor subunit alpha

Names: IL-2 receptor subunit alpha; IL-2R subunit alpha; TAC antigen; interleukin 2 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003211.2 → NP_001003211.2 interleukin-2 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_001003211.2

Status: VALIDATED

Source sequence(s)

AB501356, GU207463

UniProtKB/TrEMBL

A0A8C0PWX0, D0VYJ2, D2XMM7, F1PB00

Related

ENSCAFP00845002910.1, ENSCAFT00845003662.1

Conserved Domains (1) summary

cd00033
Location:122 → 182

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

30275012..30330188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038657725.1 → XP_038513653.1 interleukin-2 receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8C0JXU8, A0A8I3RRX4, A0A8P0ST62

Conserved Domains (1) summary

cd00033
Location:122 → 182

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_038657726.1 → XP_038513654.1 interleukin-2 receptor subunit alpha isoform X2

Conserved Domains (1) summary

cd00033
Location:61 → 121

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system