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NOS2 nitric oxide synthase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 403822, updated on 17-Aug-2024

Summary

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Official Symbol
NOS2provided by VGNC
Official Full Name
nitric oxide synthase 2provided by VGNC
Primary source
VGNC:VGNC:43895
See related
Ensembl:ENSCAFG00845014798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
INOS; NOS2A
Orthologs
human mouse all
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Genomic context

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See NOS2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (42989630..43028666, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (41328978..41365802, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (42142975..42179774, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (41770831..41807631, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (42065650..42102448, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene kinase suppressor of ras 1 Neighboring gene galectin 9 Neighboring gene transfer RNA lysine (anticodon CUU) Neighboring gene LYR motif containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis. Nagahara T, et al. J Vet Med Sci, 2022 Jan 7. PMID 34853261, Free PMC Article
  2. Expression of inducible nitric oxide synthase in macrophages inversely correlates with parasitism of lymphoid tissues in dogs with visceral leishmaniasis. Sanches FP, et al. Acta Vet Scand, 2014 Sep 7. PMID 25195062, Free PMC Article
  3. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Nishijima Y, et al. Cardiovasc Res, 2011 Jul 1. PMID 21460065, Free PMC Article
  4. Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi. dos Santos FR, et al. Parasitol Res, 2011 Jun. PMID 21188604
  5. Induction and cDNA sequence of inducible nitric oxide synthase from canine aortic smooth muscle cells. Wang X, et al. Am J Physiol, 1998 Oct. PMID 9746458

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
    Title: Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
  2. Increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
    Title: Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.
  3. demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA
    Title: Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.
  4. IL-17A gene transcription level was positively correlated with mRNA expression for iNOS and IFN-gamma
    Title: Impairment of Interleukin-17A Expression in Canine Visceral Leishmaniosis is Correlated with Reduced Interferon-γ and Inducible Nitric Oxide Synthase Expression.
  5. Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
    Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
  6. A positive correlation was found between the number of iNOS cells in lymph nodes and interferon-gamma levels, and there was a negative correlation between parasites and iNOS cell densities both in lymph nodes and spleen.
    Title: Expression of inducible nitric oxide synthase in macrophages inversely correlates with parasitism of lymphoid tissues in dogs with visceral leishmaniasis.
  7. results showed that the median expression of iNOS was higher in symptomatic dogs and oligosymptomatic dogs compared to non-infected dogs
    Title: Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi.
  8. Chronic non-ischaemic heart failure results in atrial oxidative stress and electrophysiologic abnormalities by depletion of tetrahydrobiopterin and uncoupling of NOS2.
    Title: Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.
  9. treatment with avocado/soybean unsaponifiables can reduce the development of early osteoarthritic cartilage and subchondral bone lesions. This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13
    Title: Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
  10. Inflammatory cytokines and NO form INOS may be involved in intraneural inflammatory changes arising from mechanical compression
    Title: Localization and changes of intraneural inflammatory cytokines and inducible-nitric oxide induced by mechanical compression.
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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nitric oxide synthase, inducible
Names
NOS type II
inducible NO synthase
inducible NOS
inducible nitric oxide synthase
nitric oxide synthase 2A (inducible, hepatocytes)
peptidyl-cysteine S-nitrosylase NOS2
NP_001300777.1
XP_038530887.1
XP_038530888.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313848.2 → NP_001300777.1  nitric oxide synthase, inducible

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000313
    UniProtKB/TrEMBL
    A0A8C0RKD0, A0A8C0T683, A0A8I3NVW8
    Related
    ENSCAFP00845020859.1, ENSCAFT00845026468.1
    Conserved Domains (3) summary
    cd00795
    Location:84 → 496
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:541 → 672
    Flavodoxin_1
    cl06868
    Location:736 → 1132
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    42989630..43028666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674959.1 → XP_038530887.1  nitric oxide synthase, inducible isoform X1

    UniProtKB/TrEMBL
    A0A8C0RKD0, A0A8C0T683, A0A8I3NVW8
    Related
    ENSCAFP00845020957.1, ENSCAFT00845026593.1
    Conserved Domains (3) summary
    cd00795
    Location:84 → 496
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:541 → 672
    Flavodoxin_1
    cl06868
    Location:736 → 1132
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  2. XM_038674960.1 → XP_038530888.1  nitric oxide synthase, inducible isoform X2

    UniProtKB/TrEMBL
    A0A8C0RKD9, A0A8C0T6A0, A0A8I3NZL3
    Related
    ENSCAFP00845021024.1, ENSCAFT00845026680.1
    Conserved Domains (3) summary
    cd00795
    Location:83 → 495
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:540 → 671
    Flavodoxin_1
    cl06868
    Location:735 → 1131
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    41770831..41807631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    42065650..42102448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    42142975..42179774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    41328978..41365802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003186.1: Suppressed sequence

    Description
    NM_001003186.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62699.2 GenPept UniProtKB/Swiss-Prot:O62699

Gene LinkOut

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