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CHRNA1 cholinergic receptor nicotinic alpha 1 subunit [ Canis lupus familiaris (dog) ]

Gene ID: 403757, updated on 17-Aug-2024

Summary

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Official Symbol
CHRNA1provided by VGNC
Official Full Name
cholinergic receptor nicotinic alpha 1 subunitprovided by VGNC
Primary source
VGNC:VGNC:39236
See related
Ensembl:ENSCAFG00845016336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CHRNA1 in Genome Data Viewer
Location:
chromosome: 36
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (18862735..18878999, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (18734972..18751239, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (19048764..19065033, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (18939222..18955468, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (18937561..18953818, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867834 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111094229 Neighboring gene WAS/WASL interacting protein family member 1 Neighboring gene chimerin 1 Neighboring gene uncharacterized LOC119867835 Neighboring gene uncharacterized LOC102155817 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like Neighboring gene activating transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of the canine nicotinic acetylcholine receptor alpha-subunit gene and development of the ELISA method to diagnose myasthenia gravis. Yoshioka T, et al. Vet Immunol Immunopathol, 1999 Dec 30. PMID 10628675
  2. Human nicotinic acetylcholine receptor alpha-subunit isoforms: origins and expression. MacLennan C, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265363, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
acetylcholine receptor subunit alpha
Names
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
muscle nicotinic acetylcholine receptor alpha-su exon P4
nachr alpha-subunit
nicotinic acetylcholine recepter alpha-subunit
nicotinic alpha polypeptide 1
nicotinic cholinergic receptor alpha polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003144.2 → NP_001003144.1  acetylcholine receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_001003144.1

    Status: PROVISIONAL

    Source sequence(s)
    AB021708
    UniProtKB/TrEMBL
    A0A8C0NPL2, A0A8I3NR21, Q9XS62
    Related
    ENSCAFP00845022930.1, ENSCAFT00845029156.1
    Conserved Domains (3) summary
    TIGR00860
    Location:21 → 447
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 231
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:238 → 446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    18862735..18878999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    18939222..18955468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    18937561..18953818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    19048764..19065033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18734972..18751239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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