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park - parkin

Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitochondrion organization; protein ubiquitination; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in germarium region 2b; head; oocyte; and organism. Used to study Parkinson's disease; Parkinson's disease 2; Parkinson's disease 6; cardiomyopathy; and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa