U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

smad10.L SMAD family member 10 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 403356, updated on 9-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
smad10.L
Official Full Name
SMAD family member 10 L homeolog
Primary source
Xenbase:XB-GENE-6256010
Locus tag
XELAEV_18040858mg
See related
EnsemblRapid:ENSXLAG00005003237 AllianceGenome:Xenbase:XB-GENE-6256010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
jip; dpc4; jv5-1; madh4; madh5; smad5; Smad4b; smad10; xsmad4; smad4.2; xsmad4b; Smad4beta; smad4.2-a; smad4.2-b; smad4.2.L; XSmad4beta; XSmad4alpha
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including cell differentiation; cell surface receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See smad10.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (133268444..133302861)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (118032252..118067679)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016714651.1 (61..586)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A1 L homeolog Neighboring gene protein S100-A13 Neighboring gene chromatin target of PRMT1 L homeolog Neighboring gene SNAP-associated protein L homeolog Neighboring gene interleukin enhancer binding factor 2 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Spemann organizer activity of Smad10. LeSueur JA, et al. Development, 1999 Jan. PMID 9834193
  2. Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. Masuyama N, et al. J Biol Chem, 1999 Apr 23. PMID 10207044
  3. XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos. Osada S, et al. Development, 2003 May. PMID 12642484
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC79909, MGC197190

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SMAD family member 10 L homeolog; SMAD family member 4, gene 2 L homeolog
Names
SMAD family member 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090918.1 → NP_001084387.1  SMAD family member 10 L homeolog isoform 2

    See identical proteins and their annotated locations for NP_001084387.1

    Status: PROVISIONAL

    Source sequence(s)
    AB022722
    UniProtKB/TrEMBL
    B7ZSB9, Q9PWJ9
    Related
    ENSXLAP00005009659.1, ENSXLAT00005009814.1
    Conserved Domains (2) summary
    cd10492
    Location:10 → 134
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:328 → 549
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. NM_001090989.1 → NP_001084458.1  SMAD family member 10 L homeolog isoform 1

    See identical proteins and their annotated locations for NP_001084458.1

    Status: PROVISIONAL

    Source sequence(s)
    AF104232
    UniProtKB/TrEMBL
    B7ZSB9, Q9YGP9
    Related
    ENSXLAP00005009598.1, ENSXLAT00005009752.1
    Conserved Domains (2) summary
    cd10492
    Location:45 → 169
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:363 → 584
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    133268444..133302861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041571986.1 → XP_041427920.1  SMAD family member 4, gene 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LGV7, B7ZSB9
    Related
    ENSXLAP00005009634.1, ENSXLAT00005009790.1
    Conserved Domains (3) summary
    cd10492
    Location:109 → 233
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:427 → 648
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4
    PHA03247
    Location:263 → 427
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.