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CYP21A1 cytochrome P450 family 21 subfamily A member 1 [ Sus scrofa (pig) ]

Gene ID: 403337, updated on 12-Oct-2024

Summary

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Official Symbol
CYP21A1provided by VGNC
Official Full Name
cytochrome P450 family 21 subfamily A member 1provided by VGNC
Primary source
VGNC:VGNC:103369
See related
Ensembl:ENSSSCG00000001428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CYP21; CYP21A2
Expression
Broad expression in subcutaneous adipose (RPKM 10.4), heart (RPKM 3.3) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CYP21A1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (24086138..24089364)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (27722776..27726287, complement)

Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene complement C4A (Rodgers blood group) Neighboring gene tenascin XB Neighboring gene activating transcription factor 6 beta Neighboring gene FKBP prolyl isomerase like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Expression level of the cytochrome P450c21 (CYP21) protein correlating to drip loss in pigs. Kaewkot A, et al. Anim Sci J, 2017 Nov. PMID 28677294
  2. Complete amino acid sequence of 21-hydroxylase cytochrome P-450 from porcine adrenal microsomes. Haniu M, et al. Arch Biochem Biophys, 1987 Apr. PMID 3495238
  3. The swine steroid 21-hydroxylase gene (CYP21): cloning and mapping within the swine leucocyte antigen complex. Geffrotin C, et al. Anim Genet, 1990. PMID 2109953
  4. Marked genetic polymorphism of the swine steroid 21-hydroxylase gene, and its location between the SLA class I and class II regions. Geffrotin C, et al. Anim Genet, 1991. PMID 1683187
  5. Sequences of the swine 21-hydroxylase gene (CYP21) and a portion of the opposite-strand overlapping gene of unknown function previously described in human. Burghelle-Mayeur C, et al. Biochim Biophys Acta, 1992 Dec 29. PMID 1482677

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It plays a role on cortisol production and depends on stress. And expression of CYP21 protein will provide the basis for information and better understanding of the mechanisms related to drip loss in pork.
    Title: Expression level of the cytochrome P450c21 (CYP21) protein correlating to drip loss in pigs.
  2. CYP21 gene polymorphisms were analyzed in association with litter size.
    Title: Detection of novel single-nucleotide polymorphisms (SNPs) in the CYP21 gene and association analysis of two SNPs for CYP21 and ESR2 with litter size in a commercial sow population.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid 17-alpha-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
steroid 21-hydroxylase
Names
21-OHase
FK506 binding protein like
cytochrome P-450c21
cytochrome P450 21
cytochrome P450 21-hydroxylase
cytochrome P450 XXI
cytochrome P450, family 21, subfamily A, polypepide 2
cytochrome P450-C21
NP_999598.1
XP_005665863.1
XP_005665864.1
XP_020953980.1
XP_020953981.1
XP_020953982.1
XP_020953984.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214433.1 → NP_999598.1  steroid 21-hydroxylase

    See identical proteins and their annotated locations for NP_999598.1

    Status: PROVISIONAL

    Source sequence(s)
    M83939
    UniProtKB/Swiss-Prot
    A5A8W6, P15540, Q02390
    UniProtKB/TrEMBL
    A0A8D1R6N6
    Related
    ENSSSCP00000001529.2, ENSSSCT00000001571.5
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 455
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

    Range
    24086138..24089364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021098321.1 → XP_020953980.1  steroid 21-hydroxylase isoform X1

    UniProtKB/TrEMBL
    A0A8D1WYZ6
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 557
    p450; Cytochrome P450

  2. XM_021098323.1 → XP_020953982.1  steroid 21-hydroxylase isoform X3

    UniProtKB/TrEMBL
    A0A8D1WYZ6
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 519
    p450; Cytochrome P450

  3. XM_021098322.1 → XP_020953981.1  steroid 21-hydroxylase isoform X2

    UniProtKB/TrEMBL
    A0A8D1R6N6
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 523
    p450; Cytochrome P450

  4. XM_005665807.3 → XP_005665864.1  steroid 21-hydroxylase isoform X5

    UniProtKB/TrEMBL
    A0A5G2QLE9, A0A8D1WYZ6, A0A8D2C404
    Related
    ENSSSCP00000062899.1, ENSSSCT00000074277.2
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 489
    p450; Cytochrome P450

  5. XM_005665806.3 → XP_005665863.1  steroid 21-hydroxylase isoform X4

    UniProtKB/TrEMBL
    A0A8D1R6N6
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 493
    p450; Cytochrome P450

  6. XM_021098325.1 → XP_020953984.1  steroid 21-hydroxylase isoform X6

    UniProtKB/TrEMBL
    A0A8D1R6N6
    Conserved Domains (1) summary
    pfam00067
    Location:29 → 485
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15540.2 GenPept UniProtKB/Swiss-Prot:P15540

Gene LinkOut

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