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siz schizo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40327, updated on 28-Oct-2024

Summary

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Official Symbol
sizprovided by FlyBase
Official Full Name
schizoprovided by FlyBase
Primary source
FLYBASE:FBgn0026179
Locus tag
Dmel_CG32434
See related
AllianceGenome:FB:FBgn0026179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10577; CG12980; CG12981; CG32434; Dmel\CG32434; loner; Loner; Schizo; Siz
Summary
Enables cadherin binding activity. Involved in several processes, including actin cytoskeleton organization; compound eye morphogenesis; and myoblast fusion. Predicted to be located in Golgi membrane. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; brain; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Orthologous to several human genes including IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See siz in Genome Data Viewer
Location:
78A5-78B1; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21034535..21075444)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21027635..21068544)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45945

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo. Lübke S, et al. Biol Open, 2024 Jan 15. PMID 34897417, Free PMC Article
  2. Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. Ansar M, et al. Am J Hum Genet, 2019 Nov 7. PMID 31607425, Free PMC Article
  3. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Casanova JE. Traffic, 2007 Nov. PMID 17850229
  4. Myoblasts fuse when loner meets ARF6. Donaldson JG. Dev Cell, 2003 Oct. PMID 14536050
  5. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
    Title: The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
  2. Results suggest that N-cadherin is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
    Title: The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.
  3. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
    Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cadherin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
schizo
Names
CG32434-PA
CG32434-PB
CG32434-PC
CG32434-PD
dBRAG
loner
siz-PA
siz-PB
siz-PC
siz-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21034535..21075444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168881.3 → NP_730594.1  schizo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U159, Q9VP80
    Related
    FBpp0077947
    Conserved Domains (2) summary
    cd13318
    Location:981 → 1108
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:766 → 954
    Sec7; Sec7 domain

  2. NM_001170016.1 → NP_001163487.1  schizo, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI59, Q5U112
    Conserved Domains (2) summary
    cd13318
    Location:876 → 1003
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:661 → 849
    Sec7; Sec7 domain

  3. NM_206407.2 → NP_996129.1  schizo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996129.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U112, Q7KTX2
    Conserved Domains (2) summary
    cd13318
    Location:969 → 1096
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:754 → 942
    Sec7; Sec7 domain

  4. NM_001043153.2 → NP_001036618.1  schizo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U112, Q6U9V3
    Conserved Domains (2) summary
    cd13318
    Location:866 → 993
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:651 → 839
    Sec7; Sec7 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JI59 E1JI59
Q5U112 Q5U112
Q5U159 Q5U159
Q6U9V3 Q6U9V3
Q7KTX2 Q7KTX2
Q95U36 Q95U36
Q9VP80 Q9VP80

Gene LinkOut

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