fng fringe [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fngprovided by FlyBase
Official Full Name: fringeprovided by FlyBase
Primary source: FLYBASE:FBgn0011591
Locus tag: Dmel_CG10580
See related: AllianceGenome:FB:FBgn0011591
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10580; D-fng; D-Fng; Dfng; Dmel\CG10580; fg; Fng; frg; Frg; Fringe; l(3)rG554
Summary: Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in several processes, including imaginal disc development; oogenesis; and regulation of Notch signaling pathway. Located in Golgi medial cisterna and endoplasmic reticulum. Is expressed in several structures, including embryonic/larval gut; extended germ band embryo; imaginal disc; ovariole; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to several human genes including LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) and RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 78A1-78A1; 3-47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20925891..20949512, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20918991..20942612, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
Title: Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.
Title: Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.
The function of Chi and dLMO on Notch signaling is dependent on the regulation of fng transcription.
Title: Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
Fringe modulated Notch-ligand cis interactions during Drosophila development.
Title: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.
FOXO-mediated regulation of fringe links the insulin and Notch signaling pathways in the germline stem cell niche.
Title: FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency.
Eaat1 expression is promoted by Fringe-mediated neuron-glial communication during development and suggest that Eaat1 plays an essential role in regulating central nervous system neural circuits that control locomotion in Drosophila
Title: Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.
the addition of N-acetylglucosamine is the basis for the effects of Fringe on Drosophila Notch-ligand binding
Title: In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.
suppresses effects of OFUT1 on Notch binding; decreases Serrate-Notch binding but increases Delta-Notch binding.
Title: Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.
analysis of Drosophila Notch regions that contribute to ligand binding and the modulatory influence of Fringe
Title: Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe.
molecular genetic analysis
Title: Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in compound eye development	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation, imaginal disc	IDA Inferred from Direct Assay more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc anterior/posterior pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed