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tlr18 toll-like receptor 18 [ Danio rerio (zebrafish) ]

Gene ID: 403133, updated on 2-Nov-2024

Summary

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Official Symbol
tlr18provided by ZNC
Official Full Name
toll-like receptor 18provided by ZNC
Primary source
ZFIN:ZDB-GENE-040220-2
See related
Ensembl:ENSDARG00000040249 AllianceGenome:ZFIN:ZDB-GENE-040220-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TLR1.2
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to act upstream of or within immune response and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in blood; brain; integument; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tlr18 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29391791..29405133, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29456762..29470518, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25B Neighboring gene S100 calcium binding protein A1 Neighboring gene si:ch211-113g11.6 Neighboring gene uncharacterized LOC137487914 Neighboring gene leucine rich repeat and Ig domain containing 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel Toll-like receptor 2 homologue in the large yellow croaker Larimichthys crocea. Ao J, et al. Fish Shellfish Immunol, 2016 Jan. PMID 26551050
  2. DNA-based fluorescent probes of NOS2 activity in live brains. Veetil AT, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32554491, Free PMC Article
  3. Molecular characterization and expression analysis of Toll-like receptor 21 cDNA from Paralichthys olivaceus. Gao H, et al. Fish Shellfish Immunol, 2013 Oct. PMID 23880453
  4. Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response. Shan S, et al. Vet Res, 2021 Jun 15. PMID 34130754, Free PMC Article
  5. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Yeh DW, et al. Proc Natl Acad Sci U S A, 2013 Dec 17. PMID 24282308, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
toll-like receptor 18
Names
TIR1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089350.1 → NP_001082819.1  toll-like receptor 18 precursor

    See identical proteins and their annotated locations for NP_001082819.1

    Status: PROVISIONAL

    Source sequence(s)
    AL954306
    UniProtKB/TrEMBL
    A0A8M1NCP7, A3KH14
    Related
    ENSDARP00000124565.1, ENSDART00000149289.2
    Conserved Domains (4) summary
    smart00255
    Location:653 → 791
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:345 → 519
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:362 → 390
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:53 → 98
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    29391791..29405133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158050.5 → XP_005158107.1  toll-like receptor 18 isoform X1

    See identical proteins and their annotated locations for XP_005158107.1

    UniProtKB/TrEMBL
    A0A8M1NCP7, A3KH14
    Related
    ENSDARP00000106955.1, ENSDART00000130757.3
    Conserved Domains (4) summary
    smart00255
    Location:653 → 791
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:345 → 519
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:362 → 390
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:53 → 98
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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