dnajc2 DnaJ (Hsp40) homolog, subfamily C, member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnajc2provided by ZNC
Official Full Name: DnaJ (Hsp40) homolog, subfamily C, member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1912
See related: Ensembl:ENSDARG00000070477 AllianceGenome:ZFIN:ZDB-GENE-040426-1912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zrf1; zgc:85671
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin modification-dependent histone binding activity. Predicted to be involved in 'de novo' cotranslational protein folding and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; nervous system; neural plate; pectoral fin; and segmental plate. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (1771156..1785221, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (1921843..1935908, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified histone reader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within 'de novo' cotranslational protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translational fidelity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 2

Names: zuotin related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212811.1 → NP_997976.1 dnaJ homolog subfamily C member 2

See identical proteins and their annotated locations for NP_997976.1

Status: PROVISIONAL

Source sequence(s)

BC067568

UniProtKB/Swiss-Prot

Q6NWJ4, Q7SY51

Related

ENSDARP00000094239.3, ENSDART00000103463.6

Conserved Domains (5) summary

smart00717
Location:552 → 601

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

COG5269
Location:72 → 402

ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]

cd00167
Location:552 → 599

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00226
Location:85 → 155

DnaJ; DnaJ domain

pfam16717
Location:346 → 416

RAC_head; Ribosome-associated complex head domain