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Mst77F Male-specific transcript 77F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40304, updated on 18-Sep-2024

Summary

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Official Symbol
Mst77Fprovided by FlyBase
Official Full Name
Male-specific transcript 77Fprovided by FlyBase
Primary source
FLYBASE:FBgn0086915
Locus tag
Dmel_CG3354
See related
AllianceGenome:FB:FBgn0086915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
18c; CG3354; Dmel\CG3354; ms(3)nc3; mst77F; Mst77f; MST77F; nc3; R1-18c
Summary
Involved in fertilization, exchange of chromosomal proteins and sperm chromatin condensation. Located in chromatin; nucleus; and sperm flagellum. Is expressed in elongation stage spermatid and spermatocyte. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Mst77F in Genome Data Viewer
Location:
77E8-77E8; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20816901..20818027, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20810001..20811127, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene HP1 and insulator partner protein 1 Neighboring gene uncharacterized protein Neighboring gene Protein kinase, cAMP-dependent, regulatory subunit type 1 Neighboring gene antisense RNA:CR45384 Neighboring gene antisense RNA:CR45943 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure. Kost N, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735749, Free PMC Article
  2. BAC clones generated from sheared DNA. Osoegawa K, et al. Genomics, 2007 Feb. PMID 17098394, Free PMC Article
  3. Drosophila melanogaster male germ line-specific transcripts with autosomal and Y-linked genes. Russell SR, et al. Genetics, 1993 May. PMID 8514138, Free PMC Article
  4. Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction in D. melanogaster. Park JI, et al. Proc Natl Acad Sci U S A, 2023 Apr 18. PMID 37036962, Free PMC Article
  5. Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes. Chang CH, et al. Elife, 2023 Feb 10. PMID 36763410, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that Mst77F is required for the proper compaction of spermatid chromatin following the histone-to-protamine transition, and show that Mst77F is proteolytically processed during spermiogenesis, in a way remarkably similar to mammalian P2.
    Title: The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin.
  2. An intrinsically unstructured domain in the C-terminus of Mst77F binds DNA via electrostatic interaction. This binding results in structural reorganization of the domain, which induces interaction with an N-terminal region of the protein.
    Title: Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure.
  3. Expression of Mst77F, which is a specialized linker histone-like component of sperm chromatin, and of protamine B (ProtB), which contributes to formation of condensed sperm chromatin, is regulated at three levels.
    Title: Three levels of regulation lead to protamine and Mst77F expression in Drosophila.
  4. Spermatids of ms(3)nc3 (Mst77F(1)) mutants show disturbed nuclear shaping, instability of perinuclear microtubules but no obvious chromatin condensation defects.
    Title: Distinct functions of Mst77F and protamines in nuclear shaping and chromatin condensation during Drosophila spermiogenesis.
  5. identification of functional Mst77Y genes
    Title: Functional copies of the Mst77F gene on the Y chromosome of Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in sperm DNA condensation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Male-specific transcript 77F
Names
CG3354-PA
Mst77F-PA
male sterile (3) nc3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20816901..20818027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079464.3 → NP_524188.1  Male-specific transcript 77F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524188.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16909, Q86NM1, Q9VPA8
    UniProtKB/TrEMBL
    F7VJT4, G4LU53
    Related
    FBpp0077928
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16909.1 P16909

Gene LinkOut

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