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grhprb glyoxylate reductase/hydroxypyruvate reductase b [ Danio rerio (zebrafish) ]

Gene ID: 402985, updated on 2-Nov-2024

Summary

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Official Symbol
grhprbprovided by ZNC
Official Full Name
glyoxylate reductase/hydroxypyruvate reductase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1847
See related
Ensembl:ENSDARG00000019986 AllianceGenome:ZFIN:ZDB-GENE-040426-1847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb80f04; zgc:77636; wu:fb80f04
Summary
Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in hypural; liver; pronephric duct; pronephros; and yolk syncytial layer. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See grhprb in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (19835809..19845539, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (19142872..19152602, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489997 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene ubiquitin like modifier activating enzyme 6 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 2b Neighboring gene uncharacterized LOC137495486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Anderson RA, et al. Dis Model Mech, 2020 Jun 24. PMID 32430393, Free PMC Article
  2. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884
  3. Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Nolte H, et al. J Proteome Res, 2014 Apr 4. PMID 24611545
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77636

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
NP_991248.2
XP_005168397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205685.2 → NP_991248.2  glyoxylate reductase/hydroxypyruvate reductase

    Status: VALIDATED

    Source sequence(s)
    BC065431, CR387920
    UniProtKB/TrEMBL
    A0A8M1PK16, F1QYH7, Q6P0V7
    Related
    ENSDARP00000117985.1, ENSDART00000132958.3
    Conserved Domains (2) summary
    COG1052
    Location:30 → 360
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:30 → 352
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    19835809..19845539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168340.5 → XP_005168397.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFM8, E9QCX2, Q6P0V7
    Related
    ENSDARP00000116020.1, ENSDART00000147502.3
    Conserved Domains (2) summary
    COG1052
    Location:30 → 350
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:30 → 342
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394475.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    17050..26780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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