insm1a insulinoma-associated 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insm1aprovided by ZNC
Official Full Name: insulinoma-associated 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1810
See related: Ensembl:ENSDARG00000091756 AllianceGenome:ZFIN:ZDB-GENE-040426-1810
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77257
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including sensory epithelium regeneration; sensory system development; and spinal cord motor neuron differentiation. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; optic cup; pancreas primordium; presumptive telencephalon; and trigeminal placode. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (48482924..48485354, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (48675352..48677782, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insm1a-deficient embryos were microphthalmic and displayed defects in rod and cone photoreceptor differentiation
Title: Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina.
Analaysis of the data identified Insm1a as a key regulator of retina regeneration and provide a mechanistic understanding of how Insm1a contributes to multiple phases of this process.
Title: Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina.
characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
Title: Expression of two insm1-like genes in the developing zebrafish nervous system.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pancreatic A cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within posterior lateral line neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal rod cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tissue regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transdifferentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: insulinoma-associated protein 1a

Names: insulinoma-associated 1-like protein a; zinc finger protein IA-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205644.1 → NP_991207.1 insulinoma-associated protein 1a

See identical proteins and their annotated locations for NP_991207.1

Status: PROVISIONAL

Source sequence(s)

BC065636

UniProtKB/Swiss-Prot

Q3S5C8, Q6P0F9

Related

ENSDARP00000107863.1, ENSDART00000124040.3

Conserved Domains (2) summary

sd00017
Location:211 → 231

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:271 → 293

zf-C2H2; Zinc finger, C2H2 type