oprl1 opiate receptor-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oprl1provided by ZNC
Official Full Name: opiate receptor-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040312-4
See related: Ensembl:ENSDARG00000071209 AllianceGenome:ZFIN:ZDB-GENE-040312-4
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: oprl
Summary: The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (8284792..8373698, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (8360928..8449998, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Danio rerio nociceptin receptor (drNOP) displays mixed characteristics of both NOP and kappa opioid receptors. Hence, drNOP bridges the gap between nociceptin and opiate pharmacology.
Title: Pharmacological characterization of a nociceptin receptor from zebrafish (Danio rerio).
Results show that the number of nociceptin receptor (NOP)[ZfORL] transcripts is different at each developmental stage studied, and that exposure to drugs changes the expression level and localization of NOP
Title: Expression of the nociceptin receptor during zebrafish development: influence of morphine and nociceptin.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables nociceptin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nociceptin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nociceptin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nociceptin receptor

Names: nop; opioid receptor-like protein Zf-orl

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319057.1 → NP_001305986.1 nociceptin receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

AY148348, BC162385, CT737208, CU896642, EB979080, EH581149

UniProtKB/TrEMBL

A0A8M1P286

Conserved Domains (1) summary

pfam00001
Location:60 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_205589.2 → NP_991152.1 nociceptin receptor isoform 1

See identical proteins and their annotated locations for NP_991152.1

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

AY148348, BC162385, CT737208, CU896642, EB979080, EH581149

UniProtKB/TrEMBL

B3DGG1, Q7T3Q4

Related

ENSDARP00000095906.1, ENSDART00000105135.2

Conserved Domains (1) summary

pfam00001
Location:60 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)