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cdc6 cell division cycle 6 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 402825, updated on 2-Nov-2024

Summary

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Official Symbol
cdc6provided by ZNC
Official Full Name
cell division cycle 6 homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050506-131
See related
Ensembl:ENSDARG00000009942 AllianceGenome:ZFIN:ZDB-GENE-050506-131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7145727; zgc:174506
Summary
Predicted to enable DNA replication origin binding activity. Acts upstream of or within mitotic cell cycle phase transition. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cdc6 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (11783470..11792696, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (11799849..11809075, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490409 Neighboring gene junction plakoglobin a Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 93 Neighboring gene uncharacterized LOC137490405 Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene WAS/WASL interacting protein family, member 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Yao L, et al. Hum Mol Genet, 2017 Nov 1. PMID 28985365, Free PMC Article
  2. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article
  3. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Jacob V, et al. Development, 2015 Feb 1. PMID 25564650, Free PMC Article
  4. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article
  5. Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. Li L, et al. iScience, 2023 Apr 21. PMID 37009226, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell division control protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127333.1 → NP_001120805.1  cell division control protein 6 homolog

    Status: PROVISIONAL

    Source sequence(s)
    BC154325
    UniProtKB/TrEMBL
    A8KC19
    Related
    ENSDARP00000008736.6, ENSDART00000011657.7
    Conserved Domains (3) summary
    smart01074
    Location:474 → 546
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:184 → 548
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:187 → 323
    AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    11783470..11792696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394802.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    273271..282497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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