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RhoBTB Rho-related BTB domain containing [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40249, updated on 22-Aug-2024

Summary

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Official Symbol
RhoBTBprovided by FlyBase
Official Full Name
Rho-related BTB domain containingprovided by FlyBase
Primary source
FLYBASE:FBgn0036980
Locus tag
Dmel_CG5701
See related
AllianceGenome:FB:FBgn0036980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
28574635; CG5701; Dmel\CG5701; RhoGTPase; RhoX
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in melanotic encapsulation of foreign target. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Is expressed in several structures, including apoptotic amnioserosa; embryonic/larval circulatory system; embryonic/larval nervous system; extended germ band embryo; and presumptive embryonic/larval system. Used to study idiopathic generalized epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1) and RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
77B6-77B9; 3-47 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20376242..20382398)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20369342..20375498)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene inturned Neighboring gene uncharacterized protein Neighboring gene Insulin degrading metalloproteinase Neighboring gene uncharacterized protein Neighboring gene fumble Neighboring gene antisense RNA:CR43944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. Nguyen TH, et al. G3 (Bethesda), 2020 Apr 9. PMID 32111652, Free PMC Article
  2. Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. Straub J, et al. Am J Hum Genet, 2018 Jan 4. PMID 29276004, Free PMC Article
  3. Rho GTPases and cell migration. Ridley AJ. J Cell Sci, 2001 Aug. PMID 11683406
  4. Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42. Blanke S, et al. FASEB J, 2006 Apr. PMID 16581976
  5. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho-related BTB domain containing
Names
CG5701-PA
CG5701-PB
CG5701-PC
RhoBTB-PA
RhoBTB-PB
RhoBTB-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20376242..20382398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140959.2 → NP_649216.2  Rho-related BTB domain containing, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649216.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KJ62, Q961B5, Q9VPG7
    Related
    FBpp0077843
    Conserved Domains (5) summary
    cd01873
    Location:12 → 210
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:16 → 211
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:485 → 582
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:481 → 575
    BTB; BTB/POZ domain
    cl02518
    Location:392 → 446
    BTB; BTB/POZ domain

  2. NM_001275178.1 → NP_001262107.1  Rho-related BTB domain containing, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG08, Q7KJ62
    Conserved Domains (5) summary
    cd01873
    Location:12 → 210
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:16 → 211
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:485 → 582
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:481 → 575
    BTB; BTB/POZ domain
    cl02518
    Location:392 → 446
    BTB; BTB/POZ domain

  3. NM_001275179.1 → NP_001262108.1  Rho-related BTB domain containing, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIB5, Q7KJ62
    Conserved Domains (5) summary
    cd01873
    Location:12 → 210
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:16 → 211
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:485 → 582
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:481 → 575
    BTB; BTB/POZ domain
    cl02518
    Location:392 → 446
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG08 M9PG08
M9PIB5 M9PIB5
Q7KJ62 Q7KJ62
Q9VPG7 Q9VPG7

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