U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mtr3 Mtr3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40173, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Mtr3provided by FlyBase
Official Full Name
Mtr3provided by FlyBase
Primary source
FLYBASE:FBgn0036916
Locus tag
Dmel_CG8025
See related
AllianceGenome:FB:FBgn0036916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8025; Dmel\CG8025; dMtr3; mtr3
Summary
Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC6 (exosome component 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mtr3 in Genome Data Viewer
Location:
76D4-76D4; 3-46 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19912405..19913715, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19905505..19906815, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mi-2 Neighboring gene Suppressor of Triplolethal Neighboring gene long non-coding RNA:CR32218 Neighboring gene antisense RNA:CR43889 Neighboring gene Precursor RNA processing 3 Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Su(z)12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Graham AC, et al. Mol Biol Cell, 2006 Mar. PMID 16407406, Free PMC Article
  2. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
  3. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225
  4. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Graham AC, et al. Traffic, 2009 May. PMID 19220816, Free PMC Article
  5. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Lim SJ, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23358822, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Mtr3
Names
CG8025-PA
Mtr3-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19912405..19913715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140900.5 → NP_649157.1  Mtr3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BID5, Q9VW53
    Related
    FBpp0074687
    Conserved Domains (1) summary
    cl03114
    Location:47 → 274
    RNase_PH; RNase PH-like 3'-5' exoribonucleases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BID5 Q5BID5
Q9VW53 Q9VW53

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous