cyc cycle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cycprovided by FlyBase
Official Full Name: cycleprovided by FlyBase
Primary source: FLYBASE:FBgn0023094
Locus tag: Dmel_CG8727
See related: AllianceGenome:FB:FBgn0023094
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHe7; bMAL1; Bmal1; BMAL1; CG8727; Cyc; CYC; Cycle; CYCLE; dBma1; dbmal; dBmal; dBMAL; dbmal1; dBMAL1; dCYC; Dmel\CG8727; Mop3; MOP3; TGO_CYC
Summary: Enables DNA binding activity and protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including circadian regulation of gene expression; circadian regulation of heart rate; and regulation of circadian sleep/wake cycle, sleep. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; head; pacemaker neurons; and unpaired neurons. Human ortholog(s) of this gene implicated in alcohol dependence; bipolar disorder; hypertension; and type 2 diabetes mellitus. Orthologous to human BMAL1 (basic helix-loop-helix ARNT like 1) and BMAL2 (basic helix-loop-helix ARNT like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 76C6-76C6; 3-46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19813770..19815938, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19806870..19809038, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is higher Period and Timeless and lower Cycle expression in the muscle of strains with delayed aging compared to the parental strain.
Title: Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations.
experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc, and cry expression is sufficient to drive clock expression in naive cells
Title: CLOCK stabilizes CYCLE to initiate clock function in Drosophila.
Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC E-box binding, thus enhancing the removal of CLK-CYC from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC from E-boxes
Title: CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE.
Computational dissection of CLK/CYC context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites
Title: cis-regulatory requirements for tissue-specific programs of the circadian clock.
findings show that Clk and cyc act during starvation to modulate the conflict of whether flies sleep or search for food
Title: Clock and cycle limit starvation-induced sleep loss in Drosophila.
a role of CYCLE in the post-translational regulation of the CLOCK protein.
Title: Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein.
Study shows that rhythmic transcription of per and tim involves time-of-day-specific binding of CLK-CYC and associated cycles in chromatin modifications.
Title: Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications.
Stress response genes protect against lethal effects of sleep deprivation in Drosophila
Title: Stress response genes protect against lethal effects of sleep deprivation in Drosophila.
Cwo is rhythmically expressed and directly regulated by CLK-CYC through canonical E-box sequences.
Title: A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.
Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc(0)), and Clock (Clk(Jrk)) genes
Title: Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myf5 (e-PCR), detects polymorphism
- UniSTS:507078

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to cocaine	TAS Traceable Author Statement more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in eclosion rhythm	TAS Traceable Author Statement more info	PubMed
involved_in locomotor rhythm	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic behavior	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cycle

Names: CG8727-PA; brain and muscle ARNT-like 1; cyc-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19813770..19815938 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079444.3 → NP_524168.2 cycle [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524168.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61734, O76344, Q1LZ29, Q540W7, Q9VW44

Related

FBpp0074693

Conserved Domains (5) summary

smart00091
Location:111 → 173

PAS; PAS domain

cd00130
Location:311 → 406

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:31 → 84

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:111 → 212

PAS; PAS fold

pfam14598
Location:311 → 411

PAS_11; PAS domain