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Cyp305a1 Cytochrome P450 305a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40161, updated on 2-Nov-2024

Summary

Official Symbol
Cyp305a1provided by FlyBase
Official Full Name
Cytochrome P450 305a1provided by FlyBase
Primary source
FLYBASE:FBgn0036910
Locus tag
Dmel_CG8733
See related
AllianceGenome:FB:FBgn0036910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
305a1; AAF49108.1; CG8733; Cyp305A1; CYP305A1; CYP305A1-Dm; Dmel\CG8733
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in several structures, including adult head; anterior endoderm; embryonic epipharynx; embryonic hindgut; and embryonic optic lobe primordium. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); hypertension (multiple); neonatal abstinence syndrome; nicotine dependence; and renal fibrosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2J2 (cytochrome P450 family 2 subfamily J member 2); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Cyp305a1 in Genome Data Viewer
Location:
76C6-76C6; 3-46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19810403..19813339, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19803503..19806439, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing 58 Neighboring gene karyopherin alpha1 Neighboring gene uncharacterized protein Neighboring gene cycle Neighboring gene fibp

Genomic regions, transcripts, and products

General protein information

Preferred Names
cytochrome P450 305a1
Names
CG8733-PA
Cyp305a1-PA
cytochrome P450
NP_649151.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19810403..19813339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140894.3NP_649151.1  cytochrome P450 305a1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VW43
    Related
    FBpp0074694
    Conserved Domains (1) summary
    pfam00067
    Location:30500
    p450; Cytochrome P450