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serp serpentine [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40150, updated on 18-Sep-2024

Summary

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Official Symbol
serpprovided by FlyBase
Official Full Name
serpentineprovided by FlyBase
Primary source
FLYBASE:FBgn0260653
Locus tag
Dmel_CG32209
See related
AllianceGenome:FB:FBgn0260653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32209; CG8747; CG8748; DmCDA1; Dmel\CG32209; l(3)76BDk; Serp
Summary
Enables chitin binding activity and chitin deacetylase activity. Involved in chitin-based cuticle development; cuticle chitin metabolic process; and regulation of tube length, open tracheal system. Located in several cellular components, including basement membrane; chitin-based extracellular matrix; and late endosome. Is expressed in epithelial tube; presumptive embryonic/larval system; and tracheal lumen. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See serp in Genome Data Viewer
Location:
76C2-76C2; 3-46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19700977..19708015, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19694077..19701115, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene G protein beta subunit 76C Neighboring gene vermiform Neighboring gene Transient receptor potential cation channel, mucolipin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The putative chitin deacetylases Serpentine and Vermiform have non-redundant functions during Drosophila wing development. Zhang M, et al. Insect Biochem Mol Biol, 2019 Jul. PMID 31108167
  2. EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation. Olivares-Castiñeira I, et al. PLoS Genet, 2017 Jul. PMID 28678789, Free PMC Article
  3. Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila. Pesch YY, et al. J Biol Chem, 2015 Apr 17. PMID 25737451, Free PMC Article
  4. Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development. Laurichesse Q, et al. Front Cell Dev Biol, 2021. PMID 34977007, Free PMC Article
  5. Drosophila, Chitin and Insect Pest Management. Wang Y, et al. Curr Pharm Des, 2020. PMID 32693764

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DmCDA1 (Serpentine, Serp) and DmCDA2 (Vermiform, Verm) have distinct functions during Drosophila adult wing cuticle differentiation. Chitosan staining revealed that Serp is the major enzyme responsible for chitin deacetylation during wing cuticle formation, while Verm does not seem to be needed for this process. Indeed, it is questionable whether Verm is a chitin deacetylase at all.
    Title: The putative chitin deacetylases Serpentine and Vermiform have non-redundant functions during Drosophila wing development.
  2. we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
    Title: EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation.
  3. An endosomal-retrieval machinery consisting of Rab9, retromer and actin nucleator WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) regulates selective recycling of the luminal protein Serpentine in the Drosophila trachea.
    Title: Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.
  4. Serpentine (serp) and Vermiform (verm) encode similar proteins with an LDL-receptor ligand binding motif and chitin binding and deacetylation domains and are required for the normal fibrillar structure of chitin.
    Title: serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chitin deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adult chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chitin-based extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serpentine
Names
CG32209-PB
CG32209-PC
l(3)76BDk
serp-PB
serp-PC
NP_001262062.1
NP_730444.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19700977..19708015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168811.2 → NP_730444.1  serpentine, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P23, Q9VW34
    Related
    FBpp0074721
    Conserved Domains (3) summary
    cd10974
    Location:200 → 475
    CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
    cd00112
    Location:125 → 159
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01607
    Location:48 → 105
    CBM_14; Chitin binding Peritrophin-A domain

  2. NM_001275133.1 → NP_001262062.1  serpentine, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P23, Q9VW34
    Conserved Domains (3) summary
    cd10974
    Location:200 → 475
    CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
    cd00112
    Location:125 → 159
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01607
    Location:48 → 105
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P23 Q86P23
Q9VW34 Q9VW34

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