OR2A7 olfactory receptor family 2 subfamily A member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR2A7provided by HGNC
Official Full Name: olfactory receptor family 2 subfamily A member 7provided by HGNC
Primary source: HGNC:HGNC:8234
See related: Ensembl:ENSG00000243896 AllianceGenome:HGNC:8234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OR2A21; HSDJ0798C17
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 7q35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (144257663..144264792, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (143954756..143961885, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proliferation tests, ELISA and kinase array indicated that OR2A4/7 and CHS play important roles in the proliferation of HaCaT cells and keratinocytes.
Title: Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactory receptor 2A7

Names: olfactory receptor OR7-18; olfactory receptor OR7-20; olfactory receptor, family 2, subfamily A, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005328.2 → NP_001005328.1 olfactory receptor 2A7

See identical proteins and their annotated locations for NP_001005328.1

Status: VALIDATED

Source sequence(s)

AC004889

Consensus CDS

CCDS55177.1

UniProtKB/Swiss-Prot

B2RN57, Q6IFP4, Q96R45

UniProtKB/TrEMBL

A0A126GVA9, A0A126GWD8

Related

ENSP00000493320.1, ENST00000641841.1

Conserved Domains (2) summary

cd14964
Location:25 → 51

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:24 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily