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Sfxn2 Sideroflexin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40080, updated on 18-Sep-2024

Summary

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Official Symbol
Sfxn2provided by FlyBase
Official Full Name
Sideroflexin 2provided by FlyBase
Primary source
FLYBASE:FBgn0036843
Locus tag
Dmel_CG6812
See related
AllianceGenome:FB:FBgn0036843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6812; Dmel\CG6812; SFXN3
Summary
Enables serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human SFXN2 (sideroflexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Sfxn2 in Genome Data Viewer
Location:
75F6-75F6; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19063165..19066151)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19056265..19059251)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 316 member A1 Neighboring gene Mitogen-activated protein kinase phosphatase 3 Neighboring gene long non-coding RNA:CR45386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Amorim IS, et al. J Cell Sci, 2017 Jan 15. PMID 28049716, Free PMC Article
  2. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Kory N, et al. Science, 2018 Nov 16. PMID 30442778, Free PMC Article
  3. The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. Svetec N, et al. PLoS Genet, 2016 Mar. PMID 26950216, Free PMC Article
  4. A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1. Kavi H, et al. G3 (Bethesda), 2015 Jan 27. PMID 25628309, Free PMC Article
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of one-carbon metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serine import into mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sideroflexin 2
Names
CG6812-PA
Sfxn2-PA
sideroflexin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19063165..19066151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140829.3 → NP_649086.2  sideroflexin 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649086.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SZ96, Q9VVW3
    Related
    FBpp0074792
    Conserved Domains (1) summary
    pfam03820
    Location:15 → 327
    Mtc; Tricarboxylate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVW3.2 Q9VVW3

Gene LinkOut

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