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LINC00511 long intergenic non-protein coding RNA 511 [ Homo sapiens (human) ]

Gene ID: 400619, updated on 10-Oct-2023

Summary

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Official Symbol
LINC00511provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 511provided by HGNC
Primary source
HGNC:HGNC:43564
See related
Ensembl:ENSG00000227036 AllianceGenome:HGNC:43564
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCAL5; onco-lncRNA-12
Expression
Biased expression in small intestine (RPKM 1.0), duodenum (RPKM 1.0) and 9 other tissues See more
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Genomic context

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Location:
17q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (72598041..72640472, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (73471038..73513500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (70594180..70636611, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12668 Neighboring gene long intergenic non-protein coding RNA 2003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70374994-70375570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8914 Neighboring gene Sharpr-MPRA regulatory region 1101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70382797-70383298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70383299-70383798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12669 Neighboring gene Sharpr-MPRA regulatory region 2052 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:70417088-70418287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70426388-70426888 Neighboring gene long intergenic non-protein coding RNA 673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70464235-70464912 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70472481-70473394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:70511237-70511737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70513037-70513545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70552918-70553418 Neighboring gene Sharpr-MPRA regulatory region 2461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12681 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70598976-70599943 Neighboring gene uncharacterized LOC107985005 Neighboring gene uncharacterized LOC105371887 Neighboring gene ribosomal protein L32 pseudogene 33 Neighboring gene solute carrier family 39 member 11 Neighboring gene RN7SK pseudogene 180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt/β-catenin pathway. Tan Z, et al. Mol Cell Probes, 2023 Jun. PMID 37068562
  2. Linc00511 Knockdown Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition of Bronchial Epithelial Cells by Targeting miR-16-5p/Smad3. She W, et al. Am J Rhinol Allergy, 2023 May. PMID 36594176
  3. Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of plasminogen activator urokinase. Zhang T, et al. Immunopharmacol Immunotoxicol, 2023 Jun. PMID 36476048
  4. LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis. Lu M, et al. Apoptosis, 2022 Dec. PMID 36103025, Free PMC Article
  5. IncRNA Linc00511 Upregulation Elevates TGFBR1 and Participates in the Postoperative Distant Recurrence of Non-Small-Cell Lung Cancer by Targeting miR-98-5p. Li C, et al. Crit Rev Eukaryot Gene Expr, 2022. PMID 35993940

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11.
    Title: linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11.
  2. Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of plasminogen activator urokinase.
    Title: Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of plasminogen activator urokinase.
  3. Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt/beta-catenin pathway.
    Title: Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt/β-catenin pathway.
  4. Comprehensive analysis of lncRNA-mRNA co-expression networks in HPV-driven cervical cancer reveals the pivotal function of LINC00511-PGK1 in tumorigenesis.
    Title: Comprehensive analysis of lncRNA-mRNA co-expression networks in HPV-driven cervical cancer reveals the pivotal function of LINC00511-PGK1 in tumorigenesis.
  5. Linc00511 Knockdown Inhibited TGF-beta1-Induced Epithelial-Mesenchymal Transition of Bronchial Epithelial Cells by Targeting miR-16-5p/Smad3.
    Title: Linc00511 Knockdown Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition of Bronchial Epithelial Cells by Targeting miR-16-5p/Smad3.
  6. Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3.
    Title: Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3.
  7. LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis.
    Title: LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis.
  8. IncRNA Linc00511 Upregulation Elevates TGFBR1 and Participates in the Postoperative Distant Recurrence of Non-Small-Cell Lung Cancer by Targeting miR-98-5p.
    Title: IncRNA Linc00511 Upregulation Elevates TGFBR1 and Participates in the Postoperative Distant Recurrence of Non-Small-Cell Lung Cancer by Targeting miR-98-5p.
  9. LncRNA LINC00511 promotes COL1A1-mediated proliferation and metastasis by sponging miR-126-5p/miR-218-5p in lung adenocarcinoma.
    Title: LncRNA LINC00511 promotes COL1A1-mediated proliferation and metastasis by sponging miR-126-5p/miR-218-5p in lung adenocarcinoma.
  10. LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p.
    Title: LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • lung cancer associated lncRNA 5

Clone Names

  • FLJ26484

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033876.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006948, AK129994
    Related
    ENST00000581549.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    72598041..72640472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    73471038..73513500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials