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GRAPL GRB2 related adaptor protein like [ Homo sapiens (human) ]

Gene ID: 400581, updated on 11-Apr-2024

Summary

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Official Symbol
GRAPLprovided by HGNC
Official Full Name
GRB2 related adaptor protein likeprovided by HGNC
Primary source
HGNC:HGNC:37240
See related
Ensembl:ENSG00000189152 AllianceGenome:HGNC:37240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAPLDR
Summary
Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen (RPKM 4.2), lymph node (RPKM 2.8) and 13 other tissues See more
Orthologs
all
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Genomic context

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Location:
17p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19127589..19159187)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19040890..19076910, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19030902..19062500)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 3D Neighboring gene uncharacterized LOC124903946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19026149-19026648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19030843-19031574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19044151-19044752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19044753-19045353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19046411-19046923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19047949-19048460 Neighboring gene GRAPL antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19061738-19062263 Neighboring gene kynureninase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19079065-19079566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19079567-19080066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8284 Neighboring gene small nucleolar RNA, C/D box 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in enzyme-linked receptor protein signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GRB2-related adapter protein-like
Names
GRAPL long non-coding downstream RNA
GRB2-related adapter protein LOC400581

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129778.3 → NP_001123250.1  GRB2-related adapter protein-like isoform 1

    See identical proteins and their annotated locations for NP_001123250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007952
    Consensus CDS
    CCDS45627.1
    UniProtKB/Swiss-Prot
    B2RXI8, Q8TC17
    Related
    ENSP00000437409.2, ENST00000344415.9
    Conserved Domains (2) summary
    cd11948
    Location:2 → 55
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56 → 101
    SH2; Src homology 2 (SH2) domain

  2. NM_001353418.2 → NP_001340347.1  GRB2-related adapter protein-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC007952
    Related
    ENSP00000466091.1, ENST00000577213.1
    Conserved Domains (2) summary
    cd11948
    Location:2 → 55
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56 → 100
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    19127589..19159187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024636.3 → XP_016880125.1  GRB2-related adapter protein-like isoform X2

  2. XM_011523857.4 → XP_011522159.1  GRB2-related adapter protein-like isoform X1

    UniProtKB/TrEMBL
    J3QRP9
    Conserved Domains (2) summary
    cd11948
    Location:2 → 55
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56 → 100
    SH2; Src homology 2 (SH2) domain

RNA

  1. XR_007065298.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    19040890..19076910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316107.1 → XP_054172082.1  GRB2-related adapter protein-like isoform X1

    UniProtKB/TrEMBL
    J3QRP9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TC17.3 GenPept UniProtKB/Swiss-Prot:Q8TC17

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