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Cyp12c1 Cytochrome P450 12c1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40037, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp12c1provided by FlyBase
Official Full Name
Cytochrome P450 12c1provided by FlyBase
Primary source
FLYBASE:FBgn0036806
Locus tag
Dmel_CG4120
See related
AllianceGenome:FB:FBgn0036806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12c1; CG4120; Cyp12c; cyp12c1; Cyp12C1; Dmel\CG4120
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Cyp12c1 in Genome Data Viewer
Location:
75D6-75D6; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18684259..18686319, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18677359..18679419, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Charged multivesicular body protein 1 Neighboring gene long non-coding RNA:CR43987 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detecting highly differentiated copy-number variants from pooled population sequencing. Schrider DR, et al. Pac Symp Biocomput, 2013. PMID 23424139, Free PMC Article
  2. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
  3. Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. Avery P, et al. RNA, 2011 Apr. PMID 21317294, Free PMC Article
  4. Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Giraudo M, et al. Pestic Biochem Physiol, 2010 Jun 1. PMID 20582327, Free PMC Article
  5. High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. Stobdan T, et al. PLoS One, 2019. PMID 30861021, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 12c1
Names
CG4120-PA
CG4120-PB
Cyp12c1-PA
Cyp12c1-PB
NP_001287109.1
NP_649052.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18684259..18686319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300180.1 → NP_001287109.1  cytochrome P450 12c1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVR9
    UniProtKB/TrEMBL
    X2JB94
    Conserved Domains (1) summary
    pfam00067
    Location:45 → 502
    p450; Cytochrome P450

  2. NM_140795.3 → NP_649052.1  cytochrome P450 12c1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVR9
    UniProtKB/TrEMBL
    X2JB94
    Related
    FBpp0074858
    Conserved Domains (1) summary
    pfam00067
    Location:45 → 502
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVR9.2 Q9VVR9
X2JB94 X2JB94

Gene LinkOut

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