GNBP1 Gram-negative bacteria binding protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GNBP1provided by FlyBase
Official Full Name: Gram-negative bacteria binding protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0040323
Locus tag: Dmel_CG6895
See related: AllianceGenome:FB:FBgn0040323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6895; DGNBP-1; DGNBP1; Dmel\CG6895; GNBP; GNBP 1; GNBP-1
Summary: Enables several functions, including (1->3)-beta-D-glucan binding activity; lipopolysaccharide binding activity; and peptidoglycan binding activity. Involved in several processes, including immune response-regulating signaling pathway; peptidoglycan catabolic process; and positive regulation of Toll signaling pathway. Located in extracellular space. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18675800..18677876)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18668900..18670976)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables beta-glucanase activity	IKR Inferred from Key Residues more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
NOT enables hydrolase activity	IKR Inferred from Key Residues more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
NOT involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in innate immune response-activating signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG6895-PA; GNBP1-PA; glucan-binding protein 1; gram-negative binding protein 1; osiris

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The following sections contain reference sequences that belong to a specific genome build. Explain