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Vps60 Vacuolar protein sorting 60 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39964, updated on 18-Sep-2024

Summary

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Official Symbol
Vps60provided by FlyBase
Official Full Name
Vacuolar protein sorting 60provided by FlyBase
Primary source
FLYBASE:FBgn0036740
Locus tag
Dmel_CG6259
See related
AllianceGenome:FB:FBgn0036740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-74EFb; bs36h07.y1; CG6259; Chmp5; Dchmp5; Dmel\CG6259; VPS60
Summary
Involved in viral entry into host cell. Predicted to be active in multivesicular body. Is expressed in adult head and organism. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Vps60 in Genome Data Viewer
Location:
74E2-74E2; 3-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17620123..17621625, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17613223..17614725, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclin T Neighboring gene Ecdysone-induced protein 74EF Neighboring gene small Cajal body-specific RNA : MeU4-A65 Neighboring gene long non-coding RNA:CR44566 Neighboring gene anchor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
  2. The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. Bäumers M, et al. Biol Open, 2019 Sep 2. PMID 31412999, Free PMC Article
  3. Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Marie PP, et al. J Extracell Vesicles, 2023 Mar. PMID 36872252, Free PMC Article
  4. An ESCRT module is required for neuron pruning. Loncle N, et al. Sci Rep, 2015 Feb 13. PMID 25676218, Free PMC Article
  5. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome transport via multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell HMP PubMed 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT III complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar protein sorting 60
Names
CG6259-PA
CG6259-PB
Vps60-PA
Vps60-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17620123..17621625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275065.1 → NP_001261994.1  vacuolar protein sorting 60, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVI9
    UniProtKB/TrEMBL
    M9PCV9
    Conserved Domains (1) summary
    cl21588
    Location:1 → 190
    Snf7; Snf7

  2. NM_140740.4 → NP_648997.1  vacuolar protein sorting 60, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648997.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVI9
    UniProtKB/TrEMBL
    M9PCV9
    Related
    FBpp0074964
    Conserved Domains (1) summary
    cl21588
    Location:1 → 190
    Snf7; Snf7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCV9 M9PCV9
Q9VVI9.2 Q9VVI9

Gene LinkOut

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