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MMUT methylmalonyl-CoA mutase [ Sus scrofa (pig) ]

Gene ID: 399535, updated on 17-Aug-2024

Summary

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Official Symbol
MMUTprovided by VGNC
Official Full Name
methylmalonyl-CoA mutaseprovided by VGNC
Primary source
VGNC:VGNC:98131
See related
Ensembl:ENSSSCG00000001732
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
MUT
Expression
Ubiquitous expression in liver (RPKM 71.5), kidney (RPKM 37.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See MMUT in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (43597313..43624603, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (50107559..50128711, complement)

Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S27-like Neighboring gene uncharacterized LOC102165477 Neighboring gene centromere protein Q Neighboring gene glycine-N-acyltransferase like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa). Naranjo V, et al. Anim Genet, 2008 Jun. PMID 18454807
  2. A polymorphic microsatellite located within the second intron of the methylmalonyl-CoA mutase (MUT) gene on SSC 1. Duscher S, et al. Anim Genet, 2000 Oct. PMID 11386222
  3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MUTm-B allele was associated with disease in a dominant pattern, while the MUTm AA genotype appeared to have a protective effect against bTB infection
    Title: Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylmalonyl-CoA mutase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylmalonyl-CoA mutase, mitochondrial
Names
MCM
methylmalonyl Coenzyme A mutase
methylmalonyl-CoA isomerase
NP_999570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214405.1 → NP_999570.1  methylmalonyl-CoA mutase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_999570.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ496801
    UniProtKB/Swiss-Prot
    Q8MI68, Q8MI71
    UniProtKB/TrEMBL
    A0A4X1V0F5
    Related
    ENSSSCP00000052912.1, ENSSSCT00000040446.3
    Conserved Domains (3) summary
    TIGR00640
    Location:613 → 744
    acid_CoA_mut_C; methylmalonyl-CoA mutase C-terminal domain
    PRK09426
    Location:41 → 744
    PRK09426; methylmalonyl-CoA mutase; Reviewed
    cd03679
    Location:40 → 574
    MM_CoA_mutase_alpha_like; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

    Range
    43597313..43624603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MI68.2 GenPept UniProtKB/Swiss-Prot:Q8MI68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials