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slc3a2b solute carrier family 3 member 2b [ Danio rerio (zebrafish) ]

Gene ID: 399488, updated on 2-Nov-2024

Summary

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Official Symbol
slc3a2bprovided by ZNC
Official Full Name
solute carrier family 3 member 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040122-2
See related
Ensembl:ENSDARG00000037012 AllianceGenome:ZFIN:ZDB-GENE-040122-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb519; zgc:55813; id:ibd1327; wu:fe14a07; wu:fq18d12
Summary
Predicted to enable L-alanine transmembrane transporter activity; L-leucine transmembrane transporter activity; and aromatic amino acid transmembrane transporter activity. Acts upstream of or within regulation of syncytium formation by plasma membrane fusion. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including EVL; hatching gland; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See slc3a2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26721369..26725879)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26684658..26689184)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene barrier to autointegration nuclear assembly factor 1 Neighboring gene calmodulin 3b (phosphorylase kinase, delta) Neighboring gene pyruvate carboxylase a Neighboring gene uncharacterized LOC101883097 Neighboring gene uncharacterized LOC101883049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Takesono A, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22331904, Free PMC Article
  2. Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Miao L, et al. Development, 2017 Jan 1. PMID 27913641
  3. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
  4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
  5. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-leucine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 3 member 2b
Names
solute carrier family 3 (amino acid transporter heavy chain), member 2b
solute carrier family 3, member 2 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201514.2 → NP_958922.2  solute carrier family 3 member 2b

    See identical proteins and their annotated locations for NP_958922.2

    Status: PROVISIONAL

    Source sequence(s)
    BC063982
    UniProtKB/TrEMBL
    A0A8M2B8B4, Q6P3H9
    Related
    ENSDARP00000053796.4, ENSDART00000053797.5
    Conserved Domains (3) summary
    cd11345
    Location:103 → 415
    AmyAc_SLC3A2; Alpha amylase catalytic domain found in solute carrier family 3 member 2 proteins
    COG0366
    Location:133 → 471
    AmyA; Glycosidase [Carbohydrate transport and metabolism]
    pfam16028
    Location:49 → 119
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    26721369..26725879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161337.4 → XP_005161394.1  solute carrier family 3 member 2b isoform X1

    See identical proteins and their annotated locations for XP_005161394.1

    UniProtKB/TrEMBL
    A0A8M2B8B4, Q6P3H9
    Conserved Domains (3) summary
    cd11345
    Location:103 → 415
    AmyAc_SLC3A2; Alpha amylase catalytic domain found in solute carrier family 3 member 2 proteins
    COG0366
    Location:133 → 471
    AmyA; Glycosidase [Carbohydrate transport and metabolism]
    pfam16028
    Location:49 → 119
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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