Adm2 adrenomedullin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adm2provided by RGD
Official Full Name: adrenomedullin 2provided by RGD
Primary source: RGD:1302971
See related: EnsemblRapid:ENSRNOG00000089041 AllianceGenome:RGD:1302971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Imd
Summary: Predicted to enable hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; feeding behavior; and negative regulation of blood pressure. Predicted to be located in extracellular region. Orthologous to human ADM2 (adrenomedullin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 83.5), Liver (RPKM 16.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122272808..122274594)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120393179..120394965)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130296895..130298641)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Title: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1alpha in Cardiac Fibrosis.
Title: Intermedin(1-53) Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis.
Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats.
Title: Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats.
Intermedin protects thapsigargininduced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)ATPase.
Title: Intermedin protects thapsigargin‑induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)‑ATPase.
Intermedin could be a potential candidate treatment for renal fibrosis.
Title: The protective role of intermedin in promoting angiogenesis during renal fibrosis.
Study shows that intermedin has a similar effect as 3-methyladenine, can reduce pathological neuronal injury and protect the brain against cerebral ischemia/reperfusion injury in rats by attenuating the effects of autophagy. Our findings provide evidence for intermedin's protective effects in relation to ischemic cerebrovascular diseases.
Title: Effects of intermedin on autophagy in cerebral ischemia/reperfusion injury.
Intermedin attenuated neointima formation in the rat model of carotid-artery balloon injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway.
Title: Intermedin reduces neointima formation by regulating vascular smooth muscle cell phenotype via cAMP/PKA pathway.
Results indicate that intermedin exerts anti-oxidant effects by inhibition of Nox4, and the effect can be mediated by cAMP-PKA pathway in unilateral ureteral obstruction induced renal fibrosis.
Title: Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.
Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP.
Title: Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia.
Title: Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ADM2

Names: intermedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.