tbp.L TATA-box binding protein L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tbp.L
Official Full Name: TATA-box binding protein L homeolog
Primary source: Xenbase:XB-GENE-6253887
Locus tag: XELAEV_18026772mg
See related: EnsemblRapid:ENSXLAG00005028582 AllianceGenome:Xenbase:XB-GENE-6253887
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tbp; xtbp; gtf2d; sca17; tbp-a; tbp-b; tfiid; gtf2d1; tfiidtau
Summary: Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Acts upstream of or within embryo development and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (51707321..51718772)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (50527779..50538951)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III general transcription initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: TATA-box-binding protein

Names: TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription factor; transcription initiation factor TFIID TBP subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090900.1 → NP_001084369.1 TATA-box-binding protein

See identical proteins and their annotated locations for NP_001084369.1

Status: PROVISIONAL

Source sequence(s)

BC106644

UniProtKB/Swiss-Prot

P27633, Q3KPN3

UniProtKB/TrEMBL

A0A8J1KL78

Related

ENSXLAP00005085306.1, ENSXLAT00005086968.1

Conserved Domains (1) summary

PLN00062
Location:120 → 296

PLN00062; TATA-box-binding protein; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

51707321..51718772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041562131.1 → XP_041418065.1 TATA-box-binding protein isoform X1

UniProtKB/Swiss-Prot

P27633, Q3KPN3

UniProtKB/TrEMBL

A0A8J1KL78

Conserved Domains (1) summary

PLN00062
Location:120 → 296

PLN00062; TATA-box-binding protein; Provisional