gnai1.S guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gnai1.S
Official Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 S homeolog
Primary source: Xenbase:XB-GENE-6253889
Locus tag: XELAEV_18020958mg
See related: EnsemblRapid:ENSXLAG00005009032 AllianceGenome:Xenbase:XB-GENE-6253889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gnai1; gnai1-a; gnai1-b
Summary: Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to act upstream of or within several processes, including cellular response to forskolin; positive regulation of protein localization to cell cortex; and regulation of mitotic spindle organization. Predicted to be located in several cellular components, including cell cortex; centrosome; and midbody. Predicted to be part of heterotrimeric G-protein complex. Is expressed in nervous system and urinary system. Orthologous to human GNAI1 (G protein subunit alpha i1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (71908384..71941143, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (70495205..70528290, complement)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled serotonin receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein localization to cell cortex	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(i) subunit alpha-1

Names: adenylate cyclase-inhibiting G alpha protein; alpha-subunit of G-protein, type G-alpha-i-1; guanine nucleotide-binding protein G(i), alpha-1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090896.1 → NP_001084365.1 guanine nucleotide-binding protein G(i) subunit alpha-1

See identical proteins and their annotated locations for NP_001084365.1

Status: PROVISIONAL

Source sequence(s)

BC073216

UniProtKB/Swiss-Prot

P27044, P27045, Q6GPC5

UniProtKB/TrEMBL

A0A974DEA8

Related

ENSXLAP00005026211.1, ENSXLAT00005026943.1

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

71908384..71941143 complement

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GenBank, FASTA, Sequence Viewer (Graphics)