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cdk7.L cyclin-dependent kinase 7 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399461, updated on 4-Nov-2024

Summary

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Official Symbol
cdk7.L
Official Full Name
cyclin-dependent kinase 7 L homeolog
Primary source
Xenbase:XB-GENE-485511
Locus tag
XELAEV_18008207mg
See related
EnsemblRapid:ENSXLAG00005024500 AllianceGenome:Xenbase:XB-GENE-485511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
MO15; cdk7; stk1; p40MO15
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to act upstream of or within several processes, including meiotic cell cycle; positive regulation of transcription by RNA polymerase II; and protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription factor TFIIK complex. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See cdk7.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (202869317..202883175, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (189747851..189761713, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121395473 Neighboring gene thrombospondin 4 L homeolog Neighboring gene serine incorporator 5 L homeolog Neighboring gene centromere protein H L homeolog Neighboring gene uncharacterized LOC121400939

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes. Shuttleworth J, et al. EMBO J, 1990 Oct. PMID 2209545, Free PMC Article
  2. p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes. Labbé JC, et al. EMBO J, 1994 Nov 1. PMID 7957080, Free PMC Article
  3. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. Fesquet D, et al. EMBO J, 1993 Aug. PMID 8344251, Free PMC Article
  4. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. Poon RY, et al. EMBO J, 1993 Aug. PMID 8393783, Free PMC Article
  5. MCM proteins are associated with RNA polymerase II holoenzyme. Yankulov K, et al. Mol Cell Biol, 1999 Sep. PMID 10454562, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIK complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 7
Names
40 kDa protein kinase
CDC2/CDK2,4-activating kinase
P40 MO15
cell division protein kinase 7
NP_001084361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090892.1 → NP_001084361.1  cyclin-dependent kinase 7

    See identical proteins and their annotated locations for NP_001084361.1

    Status: PROVISIONAL

    Source sequence(s)
    BC130134
    UniProtKB/Swiss-Prot
    A2BDA1, P20911
    UniProtKB/TrEMBL
    A0A974E3A0
    Related
    ENSXLAP00005073046.1, ENSXLAT00005074610.1
    Conserved Domains (2) summary
    PTZ00024
    Location:12 → 314
    PTZ00024; cyclin-dependent protein kinase; Provisional
    cd07841
    Location:17 → 314
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    202869317..202883175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20911.1 GenPept UniProtKB/Swiss-Prot:P20911

Gene LinkOut

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