pkm.S pyruvate kinase M1/2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pkm.S
Official Full Name: pyruvate kinase M1/2 S homeolog
Primary source: Xenbase:XB-GENE-485877
Locus tag: XELAEV_18020793mg
See related: EnsemblRapid:ENSXLAG00005007955 AllianceGenome:Xenbase:XB-GENE-485877
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pk; pk3; pkm; pkm2
Summary: Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and pyruvate kinase activity. Predicted to act upstream of or within cellular response to insulin stimulus; glycolytic process; and phosphorylation. Predicted to be located in cytoplasm. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (60975211..61003062)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (59569301..59597131)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables potassium ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyruvate kinase PKM

Names: CTHBP; cytosolic thyroid hormone binding protein/pyruvate kinase type M2; cytosolic thyroid hormone-binding protein; pyruvate kinase muscle isozyme; pyruvate kinase, muscle S homeolog

NP_001084341.1

EC 2.7.1.40

XP_018109690.1

EC 2.7.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090872.1 → NP_001084341.1 pyruvate kinase PKM

See identical proteins and their annotated locations for NP_001084341.1

Status: PROVISIONAL

Source sequence(s)

BC079921

UniProtKB/Swiss-Prot

Q68FC1, Q92122

UniProtKB/TrEMBL

A0A974D7M2, A0A974DEB1

Related

ENSXLAP00005022765.1, ENSXLAT00005023467.1

Conserved Domains (1) summary

cd00288
Location:38 → 526

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...