gata3.S GATA binding protein 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gata3.S
Official Full Name: GATA binding protein 3 S homeolog
Primary source: Xenbase:XB-GENE-865562
Locus tag: XELAEV_18020919mg
See related: EnsemblRapid:ENSXLAG00005009000 AllianceGenome:Xenbase:XB-GENE-865562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gata3; GATA-3; XGATA3; xgata-3
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to act upstream of or within several processes, including immune system development; regulation of epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (67640265..67659016)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (66227681..66246375)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GATA-binding factor 3

Names: transcription factor xGATA-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090866.1 → NP_001084335.1 GATA-binding factor 3

See identical proteins and their annotated locations for NP_001084335.1

Status: PROVISIONAL

Source sequence(s)

BC110754

UniProtKB/Swiss-Prot

P23773

UniProtKB/TrEMBL

A0A974DA49, Q2TAR8

Related

ENSXLAP00005026125.1, ENSXLAT00005026851.1

Conserved Domains (2) summary

smart00401
Location:305 → 354

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:309 → 359

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

67640265..67659016

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018254199.2 → XP_018109688.1 GATA-binding factor 3 isoform X2

UniProtKB/Swiss-Prot

P23773

UniProtKB/TrEMBL

A0A8J0UUF7
XM_018254200.2 → XP_018109689.1 GATA-binding factor 3 isoform X3

UniProtKB/TrEMBL

A0A8J0UXU0
XM_018254198.2 → XP_018109687.1 GATA-binding factor 3 isoform X1

UniProtKB/Swiss-Prot

P23773

UniProtKB/TrEMBL

A0A8J0UT92