wnt11b.L wingless-type MMTV integration site family, member 11B L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wnt11b.L
Official Full Name: wingless-type MMTV integration site family, member 11B L homeolog
Primary source: Xenbase:XB-GENE-6079153
Locus tag: XELAEV_18038627mg
See related: EnsemblRapid:ENSXLAG00005014835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: WNT11; wnt-11; wnt11b; xwnt11
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Genomic context

Location:: chromosome: 8L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (34311154..34317093)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (21220220..21226159)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xenopus Wnt11b is identified as a potential pronephric inducer.
Title: Xenopus Wnt11b is identified as a potential pronephric inducer.
Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants.
Title: Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants.
These results indicate that Pcdh7 plays an important role in maintaining the sensorial layer at the lateral neural crest border, which is nec- essary for the secretion of survival factors, including Wnt11b
Title: Neural crest development in Xenopus requires Protocadherin 7 at the lateral neural crest border.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a, acted across many cell diameters to orient Prickle3/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Title: Wnt proteins can direct planar cell polarity in vertebrate ectoderm.
Rcsd1 is required downstream of Wnt11 for ventricular trabeculation, terminal differentiation of cardiomyocytes and cardiac morphogenesis.
Title: The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.
Sulf1 enhances the ability of Wnt11b to activate canonical and non-canonical Wnt signaling.
Title: Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling.
Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.
Title: Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.
Data show that Wnt11b signaling can rescue reduced cardiac differentiation resulting from loss of function of GATA4 and 6 but not GATA5.
Title: Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling.
a novel regulatory system for Wnts by Secreted Frizzled-related proteins
Title: Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range.
AP-2rep is involved in the morphogenesis of the mesoderm at the gastrula stage, via the brachyury and/or Wnt pathways.
Title: Involvement of AP-2rep in morphogenesis of the axial mesoderm in Xenopus embryo.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within heart induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within neural crest cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroendocrine cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase C signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: protein Wnt-11b

Names: Protein Wnt-11; XWnt-11; maternal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.