psmd4.S proteasome 26S subunit ubiquitin receptor, non-ATPase 4 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: psmd4.S
Official Full Name: proteasome 26S subunit ubiquitin receptor, non-ATPase 4 S homeolog
Primary source: Xenbase:XB-GENE-5942188
Locus tag: XELAEV_18042999mg
See related: EnsemblRapid:ENSXLAG00005006641 AllianceGenome:Xenbase:XB-GENE-5942188
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: af-1; mcb1; psmd4; rpn10; pub-r5; xrpn10c
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (103089816..103101256)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (98103545..98114303)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xrpn10c-binding sites of Scythe act as an essential segment linking the ubiquitin/proteasome machinery to the control of proper embryonic development.
Title: Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome 26S subunit ubiquitin receptor, non-ATPase 4 S homeolog

Names: 26S proteasome subunit; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; proteasome 26S subunit, non-ATPase 4 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090827.1 → NP_001084296.1 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 S homeolog

See identical proteins and their annotated locations for NP_001084296.1

Status: PROVISIONAL

Source sequence(s)

BC097551

UniProtKB/TrEMBL

Q4V845, Q588Y7

Related

ENSXLAP00005019780.1, ENSXLAT00005020152.1

Conserved Domains (1) summary

cd01452
Location:1 → 187

VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...