fkbp1b.S FKBP prolyl isomerase 1B S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fkbp1b.S
Official Full Name: FKBP prolyl isomerase 1B S homeolog
Primary source: Xenbase:XB-GENE-17341940
Locus tag: XELAEV_18030131mg
See related: EnsemblRapid:ENSXLAG00005004731 AllianceGenome:Xenbase:XB-GENE-17341940
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: otk4; PPIase; fkbp1b; fkbp1l; pkbp1l; xfkbp1b; fkbp12.6
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within regulation of ryanodine-sensitive calcium-release channel activity. Located in terminal cisterna. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (133091757..133140288)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (126382118..126431135)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Stoichiometry of binding sites and FKBP exchange binding.
Title: FKBP binding characteristics of cardiac microsomes from diverse vertebrates.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of ryanodine-sensitive calcium-release channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in terminal cisterna	IDA Inferred from Direct Assay more info	PubMed