eif4a3.S eukaryotic translation initiation factor 4A3, gene 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: eif4a3.S
Official Full Name: eukaryotic translation initiation factor 4A3, gene 1 S homeolog
Primary source: Xenbase:XB-GENE-5773753
See related: EnsemblRapid:ENSXLAG00005007497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ddx48; nuk34; eif4a3; nmp265; ddx48-a; eif4a3-B; eif4a3-a; eif4a3.1; eif4a3.L; eif4aiii; XeIF-4AIII; eif4a3.1.S
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Genomic context

Location:: chromosome: 5S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (30451126..30469237, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (30497051..30514070, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eif4a3 is required for accurate splicing of the Xenopus laevis ryanodine receptor pre-mRNA
Title: Eif4a3 is required for accurate splicing of the Xenopus laevis ryanodine receptor pre-mRNA.
Knockdown of the EJC component Eukaryotic initiation factor 4a3 (Eif4a3) in embryos of the frog Xenopus laevis results in full-body paralysis, with defects in sensory neuron, pigment cell, and cardiac development.
Title: Regulation of vertebrate embryogenesis by the exon junction complex core component Eif4a3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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General protein information

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Preferred Names: eukaryotic initiation factor 4A-III-B

Names: ATP-dependent RNA helicase DDX48-A; ATP-dependent RNA helicase DDX48-B; ATP-dependent RNA helicase eIF4A-3-A; ATP-dependent RNA helicase eIF4A-3-B; DEAD box protein 48-A; DEAD box protein 48-B; Eukaryotic initiation factor 4A-III-A; eIF-4A-III-A; eIF-4A-III-B; eIF4A-III-A; eIF4A-III-B; eukaryotic translation initiation factor 4A3 L homeolog; eukaryotic translation initiation factor 4A3 S homeolog; eukaryotic translation initiation factor XeIF-4AIII

NP_001084200.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090731.1 → NP_001084200.1 eukaryotic initiation factor 4A-III-B

See identical proteins and their annotated locations for NP_001084200.1

Status: PROVISIONAL

Source sequence(s)

AF020432

UniProtKB/Swiss-Prot

O42226, Q5U526

Related

ENSXLAP00005021565.1, ENSXLAT00005022256.1

Conserved Domains (3) summary

PTZ00424
Location:27 → 414

PTZ00424; helicase 45; Provisional

cd00079
Location:254 → 383

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:43 → 243

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

30451126..30469237 complement

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GenBank, FASTA, Sequence Viewer (Graphics)