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fgfr2.L fibroblast growth factor receptor 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399325, updated on 18-Sep-2024

Summary

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Official Symbol
fgfr2.L
Official Full Name
fibroblast growth factor receptor 2 L homeolog
Primary source
Xenbase:XB-GENE-1018301
Locus tag
XELAEV_18034531mg
See related
EnsemblRapid:ENSXLAG00005011276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fgfr2; xfgfr2
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Genomic context

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See fgfr2.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (13829236..13901293)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (13872526..13944728)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component L homeolog Neighboring gene arginyltransferase 1 L homeolog Neighboring gene WD repeat domain 11 L homeolog Neighboring gene phospholipid phosphatase 4 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development. Friesel R, et al. Development, 1992 Dec. PMID 1284237
  2. Identification of Sef, a novel modulator of FGF signalling. Tsang M, et al. Nat Cell Biol, 2002 Feb. PMID 11802164
  3. Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2. Mathieu M, et al. J Biol Chem, 1995 Mar 24. PMID 7896824
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor 2
Names
FGFR-2
fibroblast growth factor receptor 2b
fibroblast growth factor receptor-2
NP_001084132.1
XP_018079903.1
XP_018079904.1
XP_018079905.1
XP_018079906.1
XP_018079907.1
XP_041424381.1
XP_041424382.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090663.1 → NP_001084132.1  fibroblast growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_001084132.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073456
    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    Q6GNP8
    Related
    ENSXLAP00005033153.1, ENSXLAT00005033947.1
    Conserved Domains (7) summary
    cd05857
    Location:155 → 239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262 → 351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00409
    Location:165 → 239
    IG; Immunoglobulin
    smart00410
    Location:254 → 350
    IG_like; Immunoglobulin like
    cd05101
    Location:447 → 759
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:472 → 748
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:44 → 116
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    13829236..13901293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018224415.2 → XP_018079904.1  fibroblast growth factor receptor 2 isoform X2

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A8J0T8A9
    Related
    ENSXLAP00005033163.1, ENSXLAT00005033957.1

  2. XM_041568448.1 → XP_041424382.1  fibroblast growth factor receptor 2 isoform X7

    UniProtKB/TrEMBL
    A0A679F0V0, A0A8J1L4A8
    Conserved Domains (4) summary
    smart00408
    Location:99 → 164
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:189 → 283
    IG; Immunoglobulin
    cd05101
    Location:382 → 694
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cd00096
    Location:114 → 118
    Ig; Ig strand C [structural motif]

  3. XM_018224414.2 → XP_018079903.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A8J0T8A2

  4. XM_018224416.2 → XP_018079905.1  fibroblast growth factor receptor 2 isoform X3

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A8J0T980
    Related
    ENSXLAP00005033166.1, ENSXLAT00005033960.1

  5. XM_041568447.1 → XP_041424381.1  fibroblast growth factor receptor 2 isoform X5

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A8J1L4A7
    Conserved Domains (4) summary
    smart00408
    Location:184 → 249
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:274 → 368
    IG_like; Immunoglobulin like
    cd05101
    Location:467 → 779
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    cd00096
    Location:199 → 203
    Ig; Ig strand C [structural motif]

  6. XM_018224417.2 → XP_018079906.1  fibroblast growth factor receptor 2 isoform X4

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A8J0T634

  7. XM_018224418.2 → XP_018079907.1  fibroblast growth factor receptor 2 isoform X6

    UniProtKB/Swiss-Prot
    Q03364
    UniProtKB/TrEMBL
    A0A1L8FJ12, A0A974HBB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03364.1 GenPept UniProtKB/Swiss-Prot:Q03364

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