myc.L MYC proto-oncogene, bHLH transcription factor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: myc.L
Official Full Name: MYC proto-oncogene, bHLH transcription factor L homeolog
Primary source: Xenbase:XB-GENE-6256575
Locus tag: XELAEV_18032361mg
See related: EnsemblRapid:ENSXLAG00005008307 AllianceGenome:Xenbase:XB-GENE-6256575
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: myc; cmyc; myc2; Xcmyc; c-myc; myc-B; myc-a; X-cmyc; c-myc II
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within positive regulation of cell population proliferation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (152335088..152344705)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (143182672..143186476)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings not only reveal a novel role of Mad1 in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.
Title: A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis.
Thyroid hormone activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development.(
Title: Thyroid hormone activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development.
Findings support a model in which Myc, Twist and Slug/Snail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel formation in both the vascular and lymphatic systems.
Title: A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development.
c-Myc has a direct role in the control of DNA replication
Title: Non-transcriptional control of DNA replication by c-Myc.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional regulator Myc-B

Names: MYC II; proto-oncogene c-myc II; v-myc avian myelocytomatosis viral oncogene homolog L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090653.1 → NP_001084122.1 transcriptional regulator Myc-B

See identical proteins and their annotated locations for NP_001084122.1

Status: PROVISIONAL

Source sequence(s)

X56870

UniProtKB/Swiss-Prot

P15171

Related

ENSXLAP00005023896.1, ENSXLAT00005024604.1

Conserved Domains (3) summary

cd00083
Location:334 → 393

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:6 → 327

Myc_N; Myc amino-terminal region

pfam02344
Location:391 → 419

Myc-LZ; Myc leucine zipper domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

152335088..152344705

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041565383.1 → XP_041421317.1 transcriptional regulator Myc-B isoform X1

UniProtKB/Swiss-Prot

P15171

UniProtKB/TrEMBL

A0A974HGJ8, Q6NRN4

Conserved Domains (2) summary

cd11458
Location:333 → 416

bHLHzip_c-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins

pfam01056
Location:6 → 327

Myc_N; Myc amino-terminal region