aplnr.L apelin receptor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aplnr.L
Official Full Name: apelin receptor L homeolog
Primary source: Xenbase:XB-GENE-6254056
Locus tag: XELAEV_18007385mg
See related: EnsemblRapid:ENSXLAG00005019319 AllianceGenome:Xenbase:XB-GENE-6254056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: apj; msr; Xmsr; apjr; hg11; X-msr; agtrl1; angio1; XAngio1; agtrl1a; aplnr-a; aplnr-b; agtrl1-A
Summary: Enables apelin receptor activity. Acts upstream of or within apelin receptor signaling pathway; branching involved in blood vessel morphogenesis; and regulation of angiogenesis. Located in cytoplasm and plasma membrane. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (155744413..155746646)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (142773372..142775677)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Xpreproapelin disorganized the expression of the endothelial precursor cell marker XlFli and the hematopoietic precursor cell marker SCL at the neurula.
Title: Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis.
study reports that signaling by apelin and its G protein-coupled receptor APJ is essential for embryonic angiogenesis.
Title: Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables C-C chemokine binding	IEA Inferred from Electronic Annotation more info
enables C-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables apelin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apelin receptor A

Names: APJa; G-protein coupled receptor APJ-A; angiotensin receptor related protein; angiotensin receptor-like 1a; angiotensin receptor-related protein A; mesenchyme-associated serpentine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.