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nr6a1.S nuclear receptor subfamily 6 group A member 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399304, updated on 18-Sep-2024

Summary

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Official Symbol
nr6a1.S
Official Full Name
nuclear receptor subfamily 6 group A member 1 S homeolog
Primary source
Xenbase:XB-GENE-487596
Locus tag
XELAEV_18041812mg
See related
EnsemblRapid:ENSXLAG00005023139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gcnf; xEmGCNF
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Genomic context

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See nr6a1.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (40484811..40631144, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (39977910..40125793, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 6 group A member 1-like Neighboring gene protein kinase C theta type Neighboring gene uncharacterized LOC108700025 Neighboring gene olfactomedin like 2A S homeolog Neighboring gene ribosomal protein L35 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The function of Xenopus germ cell nuclear factor (xGCNF) in morphogenetic movements during neurulation. Barreto G, et al. Dev Biol, 2003 May 15. PMID 12729562
  2. The germ cell nuclear factor is required for retinoic acid signaling during Xenopus development. Barreto G, et al. Mech Dev, 2003 Apr. PMID 12676320
  3. A role for xGCNF in midbrain-hindbrain patterning in Xenopus laevis. Song K, et al. Dev Biol, 1999 Sep 1. PMID 10452854
  4. Anteroposterior patterning and organogenesis of Xenopus laevis require a correct dose of germ cell nuclear factor (xGCNF). David R, et al. Mech Dev, 1998 Dec. PMID 10349627
  5. Oocytes and embryos of Xenopus laevis express two different isoforms of germ cell nuclear factor (GCNF, NR6A1). Schohl A, et al. Mech Dev, 2002 Oct. PMID 12351198

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. evidence pesented that illustrates the function of germ cell nuclear factor in the early development of the CNS [GCNF]
    Title: The germ cell nuclear factor is required for retinoic acid signaling during Xenopus development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 6 group A member 1
Names
germ cell nuclear factor
nr6a1
nuclear receptor subfamily 6, group A, member 1
xGCNF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090633.1 → NP_001084102.1  nuclear receptor subfamily 6 group A member 1

    See identical proteins and their annotated locations for NP_001084102.1

    Status: PROVISIONAL

    Source sequence(s)
    U58683
    UniProtKB/Swiss-Prot
    P70033, Q8JG52
    Related
    ENSXLAP00005068418.1, ENSXLAT00005069952.1
    Conserved Domains (2) summary
    cd06953
    Location:211 → 423
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07169
    Location:6 → 95
    NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    40484811..40631144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574150.1 → XP_041430084.1  nuclear receptor subfamily 6 group A member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1LLR3, A0A974C2W7
    Related
    ENSXLAP00005068521.1, ENSXLAT00005070056.1
    Conserved Domains (2) summary
    cd06953
    Location:251 → 463
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07169
    Location:46 → 135
    NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers

  2. XM_018231927.2 → XP_018087416.1  nuclear receptor subfamily 6 group A member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TEN7, A0A974C2W7
    Related
    ENSXLAP00005068511.1, ENSXLAT00005070045.1

  3. XM_018231929.2 → XP_018087418.1  nuclear receptor subfamily 6 group A member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J0TMG4, A0A974C2W7
    Related
    ENSXLAP00005068452.1, ENSXLAT00005069986.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70033.2 GenPept UniProtKB/Swiss-Prot:P70033

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials