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gata4.S GATA binding protein 4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399302, updated on 4-Nov-2024

Summary

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Official Symbol
gata4.S
Official Full Name
GATA binding protein 4 S homeolog
Primary source
Xenbase:XB-GENE-6256576
Locus tag
XELAEV_18030192mg
See related
EnsemblRapid:ENSXLAG00005004208 AllianceGenome:Xenbase:XB-GENE-6256576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gata4; gata-4; xgata4; gata4-a; gata4-b
Summary
Enables transcription cis-regulatory region binding activity. Acts upstream of or within canonical Wnt signaling pathway; cardiac muscle tissue development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in cardiovascular system and endoderm. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gata4.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (137067260..137104005, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (130364928..130401828, complement)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene cathepsin B S homeolog Neighboring gene farnesyl-diphosphate farnesyltransferase 1 S homeolog Neighboring gene family with sequence similarity 167 member A S homeolog Neighboring gene L-threonine dehydrogenase S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for GATA factors in Xenopus gastrulation movements. Fletcher G, et al. Mech Dev, 2006 Oct. PMID 16949798
  2. Wnt6 signaling regulates heart muscle development during organogenesis. Lavery DL, et al. Dev Biol, 2008 Nov 15. PMID 18804460, Free PMC Article
  3. The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Jiang Y, et al. Dev Biol, 1996 Mar 15. PMID 8631498
  4. The Kruppel-like transcription factor KLF13 is a novel regulator of heart development. Lavallée G, et al. EMBO J, 2006 Nov 1. PMID 17053787, Free PMC Article
  5. Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling. Afouda BA, et al. Dev Dyn, 2011 Mar. PMID 21305652

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
    Title: Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling.
  2. Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
    Title: Redundancy and evolution of GATA factor requirements in development of the myocardium.
  3. The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier
    Title: The Kruppel-like transcription factor KLF13 is a novel regulator of heart development.
  4. Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
    Title: A role for GATA factors in Xenopus gastrulation movements.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell fate commitment IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor GATA-4
Names
GATA-binding factor 4
transcription factor xGATA-4
xGATA-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090629.1 → NP_001084098.1  transcription factor GATA-4

    See identical proteins and their annotated locations for NP_001084098.1

    Status: PROVISIONAL

    Source sequence(s)
    U45453
    UniProtKB/Swiss-Prot
    Q91677
    UniProtKB/TrEMBL
    Q6GR27
    Related
    ENSXLAP00005012578.1, ENSXLAT00005012756.1
    Conserved Domains (4) summary
    smart00401
    Location:235 → 282
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:237 → 288
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1 → 172
    GATA-N; GATA-type transcription activator, N-terminal
    pfam08192
    Location:291 → 385
    Peptidase_S64; Peptidase family S64

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137067260..137104005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018264312.2 → XP_018119801.1  transcription factor GATA-4 isoform X1

    UniProtKB/TrEMBL
    A0A1L8G5M0, A0A974CUP7, Q6GR27
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91677.1 GenPept UniProtKB/Swiss-Prot:Q91677

Gene LinkOut

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Molecular Biology Databases
Research Materials