atp1a1.L ATPase Na+/K+ transporting subunit alpha 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atp1a1.L
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1 L homeolog
Primary source: Xenbase:XB-GENE-6254180
Locus tag: XELAEV_18011206mg
See related: EnsemblRapid:ENSXLAG00005023206 AllianceGenome:Xenbase:XB-GENE-6254180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: atp1a1; K-ATPase; atp1a1-a; atp1a1-b; atp1a1a.1; Na+K+ATPase
Summary: Enables P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within intracellular monoatomic cation homeostasis; membrane repolarization; and monoatomic cation transmembrane transport. Located in membrane. Part of sodium:potassium-exchanging ATPase complex. Is expressed in anatomical system and primary germ layer. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (716832..743929, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (709505..737044, complement)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inward current is a property inherent to Na/K pumps, not linked to the oocyte expression environment.
Title: Sodium and proton effects on inward proton transport through Na/K pumps.
The C-terminal contacts of Xenopus Na,K-ATPase alpha-1 provide important stabilization of the occluded E1P(Na3) pump conformation, regardless of the route of Na ion entry into the binding pocket.
Title: The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.
examination of ion pathway through the pump
Title: Ion permeation through the Na+,K+-ATPase.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular potassium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane repolarization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-1

Names: ATPase, Na+/K+ transporting, alpha 1 polypeptide L homeolog; Na(+)/K(+) ATPase alpha-1 subunit; Na+-K+-ATPase alpha 1 subunit; Na+/K+ ATPase; Na+K+ ATPase; sodium pump subunit alpha-1

NP_001084064.1

EC 7.2.2.13

XP_018100421.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090595.1 → NP_001084064.1 sodium/potassium-transporting ATPase subunit alpha-1

See identical proteins and their annotated locations for NP_001084064.1

Status: PROVISIONAL

Source sequence(s)

U10108

UniProtKB/Swiss-Prot

Q91683, Q92123, Q92127

UniProtKB/TrEMBL

Q6IP41

Related

ENSXLAP00005068531.1, ENSXLAT00005070065.1

Conserved Domains (6) summary

smart00831
Location:43 → 116

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:608 → 754

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:31 → 1025

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:136 → 367

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:801 → 1010

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:429 → 523

Cation_ATPase; Cation transport ATPase (P-type)