ctnnb1.L catenin beta 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ctnnb1.L
Official Full Name: catenin beta 1 L homeolog
Primary source: Xenbase:XB-GENE-6254184
Locus tag: XELAEV_18031149mg
See related: EnsemblRapid:ENSXLAG00005010445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ctnnb; ctnnb1; ctnnb1-a; ctnnb1-b; B-catenin; beta-catenin
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Genomic context

Location:: chromosome: 6L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (56678695..56695832)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (51723752..51740920)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus.
Title: β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus.
maea affects head formation through ss-catenin degradation during early Xenopus laevis development.
Title: maea affects head formation through ß-catenin degradation during early Xenopus laevis development.
We identified the amphibian leap2 gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Title: Overexpression of Leap2 impairs Xenopus embryonic development and modulates FGF and activin signals.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.
Title: Capsaicin inhibits the Wnt/β-catenin signaling pathway by down-regulating PP2A.
maternal Wnt/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Title: Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.
Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
Title: Custos controls β-catenin to regulate head development during vertebrate embryogenesis.
Wnt signalling can benefit from nucleo-cytoplasmic shuttling of APC, Axin and GSK3, although they are in general beta-catenin antagonising proteins.
Title: Analysing the impact of nucleo-cytoplasmic shuttling of β-catenin and its antagonists APC, Axin and GSK3 on Wnt/β-catenin signalling.
Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.
Title: N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
HERG channel activity is stimulated by beta-catenin
Title: Stimulation of HERG channel activity by β-catenin.
Zic3 can suppress Wnt/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Title: Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catenin beta-1

Names: beta catenin; catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090576.1 → NP_001084045.1 catenin beta-1

See identical proteins and their annotated locations for NP_001084045.1

Status: PROVISIONAL

Source sequence(s)

BC082826

UniProtKB/Swiss-Prot

P26233

UniProtKB/TrEMBL

A0A974HFG4, Q63ZT4

Related

ENSXLAP00005030792.1, ENSXLAT00005031557.1

Conserved Domains (3) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:399 → 518

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]