tubg1.L tubulin gamma 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tubg1.L
Official Full Name: tubulin gamma 1 L homeolog
Primary source: Xenbase:XB-GENE-866048
Locus tag: XELAEV_18002398mg
See related: EnsemblRapid:ENSXLAG00005031655 AllianceGenome:Xenbase:XB-GENE-866048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: xgam; Tubg2; tubg1
Summary: Enables microtubule nucleator activity and tubulin binding activity. Involved in microtubule nucleation. Part of gamma-tubulin complex. Is expressed in dermal system; nervous system; and urinary system. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to human TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (20048564..20072014, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694821.1 (28538..51854, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that depletion of either gamma-tubulin or XMAP215 was partially rescued by adding back XMAP215, but not by adding any of the other factors.
Title: Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables microtubule nucleator activity	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within microtubule nucleation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic sister chromatid segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polar microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin gamma-1 chain

Names: gamma-1-tubulin; gamma-tubulin; tubulin, gamma 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090573.1 → NP_001084042.1 tubulin gamma-1 chain

See identical proteins and their annotated locations for NP_001084042.1

Status: PROVISIONAL

Source sequence(s)

BC097771

UniProtKB/Swiss-Prot

P23330

UniProtKB/TrEMBL

Q4QQZ8

Related

ENSXLAP00005094921.1, ENSXLAT00005096633.1

Conserved Domains (1) summary

cd02188
Location:3 → 435

gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

20048564..20072014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)