msi1.S musashi RNA binding protein 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: msi1.S
Official Full Name: musashi RNA binding protein 1 S homeolog
Primary source: Xenbase:XB-GENE-865981
Locus tag: XELAEV_18010457mg
See related: EnsemblRapid:ENSXLAG00005014400 AllianceGenome:Xenbase:XB-GENE-865981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: msi1; msi-1; msi1h; XNrp-1; Musashi; Musashi1; Musashi-1
Summary: Predicted to enable mRNA binding activity. Predicted to act upstream of or within central nervous system development and regulation of translation. Predicted to be located in cytoplasm. Is expressed in nervous system. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1S

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (140687117..140710102, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (124979505..125002471, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide analysis of CPEB1- and Msi1-associated mRNAs identified 491 common targets, thus revealing a new layer of cytoplasmic polyadenylation elements-mediated translational control.
Title: Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs.
specific association of Musashi with the noncanonical poly(A) polymerase germ line development defective-2 (GLD2)
Title: Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2.
Xenopus Musashi proteins regulate translation of the Musashi1 mRNA during oocyte maturation.
Title: Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation.
Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
Title: Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.
Title: Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation.
Msi-1 expression is upregulated in the adult progenitor cells and plays important roles in their maintenance and/or active proliferation during amphibian gastrointestinal remodeling.
Title: Thyroid hormone-upregulated expression of Musashi-1 is specific for progenitor cells of the adult epithelium during amphibian gastrointestinal remodeling.
Visual deprivation for 2 days increased proliferation of musashi1-immunoreactive radial glial progenitors
Title: Visual activity regulates neural progenitor cells in developing xenopus CNS through musashi1.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: musashi RNA binding protein 1 S homeolog

Names: Musashi 1; musashi RNA-binding protein 1; musashi homolog 1; nrp-1B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090571.1 → NP_001084040.1 musashi RNA binding protein 1 S homeolog

See identical proteins and their annotated locations for NP_001084040.1

Status: PROVISIONAL

Source sequence(s)

M34894

UniProtKB/TrEMBL

A0A974I5H7, Q91807

Related

ENSXLAP00005042181.1, ENSXLAT00005043247.1

Conserved Domains (4) summary

COG0724
Location:11 → 161

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12323
Location:110 → 183

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12759
Location:20 → 96

RRM1_MSI1; RNA recognition motif 1 in RNA-binding protein Musashi homolog 1 (Musashi-1) and similar proteins

TIGR01661
Location:106 → 346

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

140687117..140710102 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018235162.2 → XP_018090651.1 musashi RNA binding protein 1 S homeolog isoform X4

UniProtKB/TrEMBL

A0A974DUQ8, A0A974I5H7, Q5U4T5

Related

ENSXLAP00005042187.1, ENSXLAT00005043253.1
XM_018235154.2 → XP_018090643.1 musashi RNA binding protein 1 S homeolog isoform X3

UniProtKB/TrEMBL

A0A8J0TSY5, A0A974I5H7
XM_018235145.2 → XP_018090634.1 musashi RNA binding protein 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8HQ70, A0A974DWF8, A0A974I5H7
XM_041574397.1 → XP_041430331.1 musashi RNA binding protein 1 S homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1LM96, A0A974E1Y2

Related

ENSXLAP00005042148.1, ENSXLAT00005043214.1

Conserved Domains (3) summary

TIGR01628
Location:14 → 306

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:92 → 165

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12759
Location:3 → 78

RRM1_MSI1; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 1 (Musashi-1) and similar proteins