hoxd1.S homeobox D1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hoxd1.S
Official Full Name: homeobox D1 S homeolog
Primary source: Xenbase:XB-GENE-482735
Locus tag: XELAEV_18047201mg
See related: AllianceGenome:Xenbase:XB-GENE-482735
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: lab; Xlab; hoxd1; Xlab-1; xhoxd1; Xhox.lab; Xhox.lab1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hindbrain development. Predicted to be located in nucleus. Is expressed in ectoderm; mesoderm; nervous system; and pharyngeal arch. Orthologous to human HOXD1 (homeobox D1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9_10S

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (68818412..68821437, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (62162023..62164125, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hoxd1 is transcriptionally induced by the Wnt/beta-catenin signaling pathway during anteroposterior patterning of the neural axis.
Title: Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus.
When Hoxa1, Hoxb1 and Hoxd1 are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
Title: Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: homeobox protein Hox-D1

Names: hox.lab1; labial protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090566.1 → NP_001084035.1 homeobox protein Hox-D1

See identical proteins and their annotated locations for NP_001084035.1

Status: PROVISIONAL

Source sequence(s)

M63873

UniProtKB/Swiss-Prot

Q08820

Conserved Domains (1) summary

pfam00046
Location:205 → 257

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

68818412..68821437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041577720.1 → XP_041433654.1 homeobox protein Hox-D1 isoform X1

UniProtKB/Swiss-Prot

Q08820, Q3KQ36, Q91767, Q91772

UniProtKB/TrEMBL

A0A1L8EP93, A0A974BUN6

Conserved Domains (1) summary

pfam00046
Location:204 → 257

Homeobox; Homeobox domain