mdk.L midkine L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mdk.L
Official Full Name: midkine L homeolog
Primary source: Xenbase:XB-GENE-6254190
Locus tag: XELAEV_18021877mg
See related: EnsemblRapid:ENSXLAG00005024277 AllianceGenome:Xenbase:XB-GENE-6254190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mdk; MK-B; mdk-a; mdk-b; negf2; ptf-a; ptf-b; midkine; ptf-beta; ptf-alpha; PTF-alpha-1
Summary: Predicted to enable heparan sulfate proteoglycan binding activity and heparin binding activity. Predicted to act upstream of or within nervous system development; neuromuscular junction development; and response to bacterium. Predicted to be located in extracellular region. Is expressed in nervous system; pharyngeal arch; vestibuloauditory system; and visual system. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (9589964..9602987, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (9049994..9063197, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular junction development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: midkine-B

Names: PTF-alpha-2; X-PTF-alpha2; midkine (neurite growth-promoting factor 2) L homeolog; pleiotrophic factor-alpha-2; pleiotrophic factor-alpha2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.